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Lipase Maturation Factor 2 (LMF2)

TMEM153; TMEM112B; Transmembrane Protein 153

Lipase Maturation Factor 2(LMF2) belongs to the lipase maturation factor family.Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway.
The disorder is caused by a decrease in the activity of lipoprotein lipase (LPL) and the related enzyme hepatic lipase, caused by impaired maturation of nascent LPL and hepatic lipase polypeptides in the endoplasmic reticulum (Briquet-Laugier et al., 1999). Peterfy et al. (2007) identified the gene containing the cld mutation as Tmem112 and renamed it Lmf1 for 'lipase maturation factor-1.' They identified the mutation as a murine endogenous retrovirus (MuERV) insertion in intron 7 resulting in truncation of the protein.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS606Hu01 Recombinant Lipase Maturation Factor 2 (LMF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS606Hu01 Monoclonal Antibody to Lipase Maturation Factor 2 (LMF2) WB; IHC; ICC; IP.
PAS606Hu01 Polyclonal Antibody to Lipase Maturation Factor 2 (LMF2) WB; IHC; ICC; IF.
Assay Kits CLS606Hu01 CLIA Kit for Lipase Maturation Factor 2 (LMF2) CLIA assay for Antigen Detection
ELS606Hu01 ELISA Kit for Lipase Maturation Factor 2 (LMF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS606Mu01 Recombinant Lipase Maturation Factor 2 (LMF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS606Mu01 Monoclonal Antibody to Lipase Maturation Factor 2 (LMF2) WB; IHC; ICC; IP.
PAS606Mu01 Polyclonal Antibody to Lipase Maturation Factor 2 (LMF2) WB; IHC; ICC; IF.
Assay Kits CLS606Mu01 CLIA Kit for Lipase Maturation Factor 2 (LMF2) CLIA assay for Antigen Detection
ELS606Mu01 ELISA Kit for Lipase Maturation Factor 2 (LMF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS606Ra01 Recombinant Lipase Maturation Factor 2 (LMF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS606Ra01 Monoclonal Antibody to Lipase Maturation Factor 2 (LMF2) WB; IHC; ICC; IP.
PAS606Ra01 Polyclonal Antibody to Lipase Maturation Factor 2 (LMF2) WB; IHC; ICC; IF.
Assay Kits CLS606Ra01 CLIA Kit for Lipase Maturation Factor 2 (LMF2) CLIA assay for Antigen Detection
ELS606Ra01 ELISA Kit for Lipase Maturation Factor 2 (LMF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS606Ca01 Recombinant Lipase Maturation Factor 2 (LMF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS606Ca01 Monoclonal Antibody to Lipase Maturation Factor 2 (LMF2) WB; IHC; ICC; IP.
PAS606Ca01 Polyclonal Antibody to Lipase Maturation Factor 2 (LMF2) WB; IHC; ICC; IF.
Assay Kits CLS606Ca01 CLIA Kit for Lipase Maturation Factor 2 (LMF2) CLIA assay for Antigen Detection
ELS606Ca01 ELISA Kit for Lipase Maturation Factor 2 (LMF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS606Po01 Recombinant Lipase Maturation Factor 2 (LMF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS606Po01 Monoclonal Antibody to Lipase Maturation Factor 2 (LMF2) WB; IHC; ICC; IP.
PAS606Po01 Polyclonal Antibody to Lipase Maturation Factor 2 (LMF2) WB; IHC; ICC; IF.
Assay Kits CLS606Po01 CLIA Kit for Lipase Maturation Factor 2 (LMF2) CLIA assay for Antigen Detection
ELS606Po01 ELISA Kit for Lipase Maturation Factor 2 (LMF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS606Bo01 Recombinant Lipase Maturation Factor 2 (LMF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS606Bo01 Monoclonal Antibody to Lipase Maturation Factor 2 (LMF2) WB; IHC; ICC; IP.
PAS606Bo01 Polyclonal Antibody to Lipase Maturation Factor 2 (LMF2) WB; IHC; ICC; IF.
Assay Kits CLS606Bo01 CLIA Kit for Lipase Maturation Factor 2 (LMF2) CLIA assay for Antigen Detection
ELS606Bo01 ELISA Kit for Lipase Maturation Factor 2 (LMF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS606Rb01 Recombinant Lipase Maturation Factor 2 (LMF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS606Rb01 Monoclonal Antibody to Lipase Maturation Factor 2 (LMF2) WB; IHC; ICC; IP.
PAS606Rb01 Polyclonal Antibody to Lipase Maturation Factor 2 (LMF2) WB; IHC; ICC; IF.
Assay Kits CLS606Rb01 CLIA Kit for Lipase Maturation Factor 2 (LMF2) CLIA assay for Antigen Detection
ELS606Rb01 ELISA Kit for Lipase Maturation Factor 2 (LMF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS606Mo01 Recombinant Lipase Maturation Factor 2 (LMF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS606Mo01 Monoclonal Antibody to Lipase Maturation Factor 2 (LMF2) WB; IHC; ICC; IP.
PAS606Mo01 Polyclonal Antibody to Lipase Maturation Factor 2 (LMF2) WB; IHC; ICC; IF.
Assay Kits CLS606Mo01 CLIA Kit for Lipase Maturation Factor 2 (LMF2) CLIA assay for Antigen Detection
ELS606Mo01 ELISA Kit for Lipase Maturation Factor 2 (LMF2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia."
Nat. Genet. 39:1483-1487(2007) [PubMed] [Europe PMC] [Abstract]

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