Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5)
PC5; PC6; PC6A; SPC6; Subtilisin/kexin-like protease PC5; Proprotein convertase 5
Proprotein convertase subtilisin/kexin type 5 is an enzyme belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein mediates posttranslational endoproteolytic processing for several integrin alpha subunits. It is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Two alternatively spliced transcripts are described for this gene but only one has its full length nature known. Expressed in T-lymphocytes. Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS600Hu01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS600Hu01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | WB; IHC; ICC; IP. |
| PAS600Hu01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS600Hu01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | CLIA assay for Antigen Detection |
| ELS600Hu01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS600Mu01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS600Mu01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | WB; IHC; ICC; IP. |
| PAS600Mu01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS600Mu01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | CLIA assay for Antigen Detection |
| ELS600Mu01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS600Ra01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS600Ra01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | WB; IHC; ICC; IP. |
| PAS600Ra01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS600Ra01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | CLIA assay for Antigen Detection |
| ELS600Ra01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS600Ca01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS600Ca01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | WB; IHC; ICC; IP. |
| PAS600Ca01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS600Ca01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | CLIA assay for Antigen Detection |
| ELS600Ca01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS600Po01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS600Po01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | WB; IHC; ICC; IP. |
| PAS600Po01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS600Po01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | CLIA assay for Antigen Detection |
| ELS600Po01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS600Bo01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS600Bo01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | WB; IHC; ICC; IP. |
| PAS600Bo01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS600Bo01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | CLIA assay for Antigen Detection |
| ELS600Bo01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS600Rb01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS600Rb01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | WB; IHC; ICC; IP. |
| PAS600Rb01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS600Rb01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | CLIA assay for Antigen Detection |
| ELS600Rb01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS600Mo01 | Recombinant Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS600Mo01 | Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | WB; IHC; ICC; IP. |
| PAS600Mo01 | Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS600Mo01 | CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | CLIA assay for Antigen Detection |
| ELS600Mo01 | ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Isolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4+ T lymphocytes."
Proc. Natl. Acad. Sci. U.S.A. 93:7695-7700(1996) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Proteomic identification of caldesmon as a physiological substrate of proprotein convertase 6 in human uterine decidual cells essential for pregnancy establishment."
J. Proteome Res. 8:4983-4992(2009) [PubMed] [Europe PMC] [Abstract]
"Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment."
Endocrinology 151:3909-3917(2010) [PubMed] [Europe PMC] [Abstract]
"Cleavage of endometrial alpha-integrins into their functional forms is mediated by proprotein convertase 5/6."
Hum. Reprod. 27:2766-2774(2012) [PubMed] [Europe PMC] [Abstract]