Baculoviral IAP Repeat Containing Protein 6 (BIRC6)

BRUCE; Apollon; BIR repeat-containing ubiquitin-conjugating enzyme; Ubiquitin-conjugating BIR domain enzyme apollon

SPN	S552
HGNC	13516
MGI	1276108
PubMed	23287853
RGD	1307247
UniProt	Q9NR09
Wiki	BIRC6

Baculoviral IAP repeat-containing protein 6 is a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.

Reference

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"A human IAP-family gene, apollon, expressed in human brain cancer cells."
Biochem. Biophys. Res. Commun. 264:847-854(1999) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]

"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]

"Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis."
EMBO J. 23:800-810(2004) [PubMed] [Europe PMC] [Abstract]

"Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase."
Mol. Cell 14:801-811(2004) [PubMed] [Europe PMC] [Abstract]

"An Apollon vista of death and destruction."
Nat. Cell Biol. 6:804-806(2004) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"Final stages of cytokinesis and midbody ring formation are controlled by BRUCE."
Cell 132:832-845(2008) [PubMed] [Europe PMC] [Abstract]

"IAPs: more than just inhibitors of apoptosis proteins."
Cell Cycle 7:1036-1046(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Ubc domain of the ubiquitin-protein ligase baculoviral IAP repeat-containing protein 6."
Submitted (APR-2008) to the PDB data bank