Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3)
Procollagen-Proline,2-Oxoglutarate 4-Dioxygenase(Proline 4-Hydroxylase),Alpha Polypeptide III
P4HA3 encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. P4HA3 has all residues necessary to bind the peptide substrate, to coordinate Fe(2+) and the 2-oxoglutarate cosubstrate, and for enzymatic activity. Processed P4HA3 contains 525 amino acids and shares 91% and 94% amino acid identity with rat and mouse P4ha3, respectively, and 35% and 37% identity with P4HA1 and P4HA2, respectively. Northern blot analysis detected a 2.7-kb P4HA3 transcript. Highest expression was in placenta, adult liver, and fetal skin, with lower levels in fetal liver, lung, and muscle. RT-PCR detected P4HA3 expression in all tissues examined, with highest expression in placenta and fetal kidney, liver, and lung. Expression of P4HA3 was much lower than that of P4HA1.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS530Hu01 | Recombinant Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS530Hu01 | Monoclonal Antibody to Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | WB; IHC; ICC; IP. |
| PAS530Hu01 | Polyclonal Antibody to Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS530Hu01 | CLIA Kit for Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | CLIA assay for Antigen Detection |
| ELS530Hu01 | ELISA Kit for Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS530Mu01 | Recombinant Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS530Mu01 | Monoclonal Antibody to Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | WB; IHC; ICC; IP. |
| PAS530Mu01 | Polyclonal Antibody to Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS530Mu01 | CLIA Kit for Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | CLIA assay for Antigen Detection |
| ELS530Mu01 | ELISA Kit for Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS530Ra01 | Recombinant Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS530Ra01 | Monoclonal Antibody to Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | WB; IHC; ICC; IP. |
| PAS530Ra01 | Polyclonal Antibody to Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS530Ra01 | CLIA Kit for Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | CLIA assay for Antigen Detection |
| ELS530Ra01 | ELISA Kit for Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS530Ca01 | Recombinant Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS530Ca01 | Monoclonal Antibody to Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | WB; IHC; ICC; IP. |
| PAS530Ca01 | Polyclonal Antibody to Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS530Ca01 | CLIA Kit for Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | CLIA assay for Antigen Detection |
| ELS530Ca01 | ELISA Kit for Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS530Po01 | Recombinant Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS530Po01 | Monoclonal Antibody to Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | WB; IHC; ICC; IP. |
| PAS530Po01 | Polyclonal Antibody to Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS530Po01 | CLIA Kit for Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | CLIA assay for Antigen Detection |
| ELS530Po01 | ELISA Kit for Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS530Bo01 | Recombinant Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS530Bo01 | Monoclonal Antibody to Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | WB; IHC; ICC; IP. |
| PAS530Bo01 | Polyclonal Antibody to Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS530Bo01 | CLIA Kit for Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | CLIA assay for Antigen Detection |
| ELS530Bo01 | ELISA Kit for Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS530Rb01 | Recombinant Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS530Rb01 | Monoclonal Antibody to Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | WB; IHC; ICC; IP. |
| PAS530Rb01 | Polyclonal Antibody to Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS530Rb01 | CLIA Kit for Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | CLIA assay for Antigen Detection |
| ELS530Rb01 | ELISA Kit for Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS530Mo01 | Recombinant Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS530Mo01 | Monoclonal Antibody to Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | WB; IHC; ICC; IP. |
| PAS530Mo01 | Polyclonal Antibody to Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS530Mo01 | CLIA Kit for Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | CLIA assay for Antigen Detection |
| ELS530Mo01 | ELISA Kit for Prolyl-4-Hydroxylase Alpha Polypeptide III (P4Ha3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme."
J. Biol. Chem. 278:47685-47693(2003) [PubMed] [Europe PMC] [Abstract]
"Cloning of a novel prolyl 4-hydroxylase subunit expressed in the fibrous cap of human atherosclerotic plaque."
Circulation 108:508-511(2003) [PubMed] [Europe PMC] [Abstract]
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Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
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Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]