Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3)
LH3; Lysyl hydroxylase 3
The LH3 cDNA clones encode a 738-amino acid polypeptide, including a signal peptide of 24 residues. The overall amino acid sequence identity between the processed human PLOD3 and PLOD1 polypeptides is 59%, and that between the processed PLOD3 and PLOD2 polypeptides is 57%, whereas the identity to the processed Caenorhabditis elegans polypeptide is only 45%. All 4 critical residues at the catalytic site, 2 histidines, 1 aspartate, and 1 arginine, are conserved in all of these polypeptides. The mRNA for PLOD3 was found to be expressed in a variety of tissues, but distinct differences appeared to exist in the expression pattern of the 3 isoenzyme mRNAs. Recombinant PLOD3 expressed in insect cells by means of a baculovirus vector was found to be more soluble than PLOD1 expressed in the same cell type.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS527Hu01 | Recombinant Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS527Hu01 | Monoclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | WB; IHC; ICC; IP. |
| PAS527Hu01 | Polyclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS527Hu01 | CLIA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | CLIA assay for Antigen Detection |
| ELS527Hu01 | ELISA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS527Mu01 | Recombinant Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS527Mu01 | Monoclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | WB; IHC; ICC; IP. |
| PAS527Mu01 | Polyclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS527Mu01 | CLIA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | CLIA assay for Antigen Detection |
| ELS527Mu01 | ELISA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS527Ra01 | Recombinant Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS527Ra01 | Monoclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | WB; IHC; ICC; IP. |
| PAS527Ra01 | Polyclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS527Ra01 | CLIA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | CLIA assay for Antigen Detection |
| ELS527Ra01 | ELISA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS527Ca01 | Recombinant Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS527Ca01 | Monoclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | WB; IHC; ICC; IP. |
| PAS527Ca01 | Polyclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS527Ca01 | CLIA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | CLIA assay for Antigen Detection |
| ELS527Ca01 | ELISA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS527Po01 | Recombinant Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS527Po01 | Monoclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | WB; IHC; ICC; IP. |
| PAS527Po01 | Polyclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS527Po01 | CLIA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | CLIA assay for Antigen Detection |
| ELS527Po01 | ELISA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS527Bo01 | Recombinant Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS527Bo01 | Monoclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | WB; IHC; ICC; IP. |
| PAS527Bo01 | Polyclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS527Bo01 | CLIA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | CLIA assay for Antigen Detection |
| ELS527Bo01 | ELISA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS527Rb01 | Recombinant Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS527Rb01 | Monoclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | WB; IHC; ICC; IP. |
| PAS527Rb01 | Polyclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS527Rb01 | CLIA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | CLIA assay for Antigen Detection |
| ELS527Rb01 | ELISA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS527Mo01 | Recombinant Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS527Mo01 | Monoclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | WB; IHC; ICC; IP. |
| PAS527Mo01 | Polyclonal Antibody to Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS527Mo01 | CLIA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | CLIA assay for Antigen Detection |
| ELS527Mo01 | ELISA Kit for Procollagen Lysine-2-Oxoglutarate-5-Dioxygenase 3 (PLOD3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Primary structure, tissue distribution, and chromosomal localization of a novel isoform of lysyl hydroxylase (lysyl hydroxylase 3)."
J. Biol. Chem. 273:12881-12886(1998) [PubMed] [Europe PMC] [Abstract]
"Cloning and characterization of a third human lysyl hydroxylase isoform."
Proc. Natl. Acad. Sci. U.S.A. 95:10482-10486(1998) [PubMed] [Europe PMC] [Abstract]
"Complete exon-intron organization of the gene for human lysyl hydroxylase 3 (LH3)."
Matrix Biol. 19:73-79(2000) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"A connective tissue disorder caused by mutations of the lysyl hydroxylase 3 gene."
Am. J. Hum. Genet. 83:495-503(2008) [PubMed] [Europe PMC] [Abstract]