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B-Lymphoid Tyrosine Kinase (BLK)

Tyrosine-protein kinase BLK; p55-Blk

The BLK gene is a nonreceptor protein tyrosine kinase with a calculated molecular mass of about 58 kD. It has an overall amino acid identity of approximately 87% to the mouse Blk; however, in the unique domain of Src family members there is only 58% homology and an insertion of 6 amino acids in the N-terminal region. The nature of this insertion suggested a functional role in membrane attachment. Mutation screening of each exon by direct sequencing of genomic DNA from KWE patients did not reveal any pathogenic mutation. Because BLK is a member of the SRC family, which is thought to play an important role in the signaling pathways controlling cell proliferation and differentiation, the authors considered the gene to be a good positional candidate for the cancers mapping to this region.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS516Hu01 Recombinant B-Lymphoid Tyrosine Kinase (BLK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS516Hu01 Monoclonal Antibody to B-Lymphoid Tyrosine Kinase (BLK) WB; IHC; ICC; IP.
PAS516Hu01 Polyclonal Antibody to B-Lymphoid Tyrosine Kinase (BLK) WB; IHC; ICC; IF.
Assay Kits CLS516Hu01 CLIA Kit for B-Lymphoid Tyrosine Kinase (BLK) CLIA assay for Antigen Detection
ELS516Hu01 ELISA Kit for B-Lymphoid Tyrosine Kinase (BLK) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS516Mu01 Recombinant B-Lymphoid Tyrosine Kinase (BLK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS516Mu01 Monoclonal Antibody to B-Lymphoid Tyrosine Kinase (BLK) WB; IHC; ICC; IP.
PAS516Mu01 Polyclonal Antibody to B-Lymphoid Tyrosine Kinase (BLK) WB; IHC; ICC; IF.
Assay Kits CLS516Mu01 CLIA Kit for B-Lymphoid Tyrosine Kinase (BLK) CLIA assay for Antigen Detection
ELS516Mu01 ELISA Kit for B-Lymphoid Tyrosine Kinase (BLK) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS516Ra01 Recombinant B-Lymphoid Tyrosine Kinase (BLK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS516Ra01 Monoclonal Antibody to B-Lymphoid Tyrosine Kinase (BLK) WB; IHC; ICC; IP.
PAS516Ra01 Polyclonal Antibody to B-Lymphoid Tyrosine Kinase (BLK) WB; IHC; ICC; IF.
Assay Kits CLS516Ra01 CLIA Kit for B-Lymphoid Tyrosine Kinase (BLK) CLIA assay for Antigen Detection
ELS516Ra01 ELISA Kit for B-Lymphoid Tyrosine Kinase (BLK) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS516Ca01 Recombinant B-Lymphoid Tyrosine Kinase (BLK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS516Ca01 Monoclonal Antibody to B-Lymphoid Tyrosine Kinase (BLK) WB; IHC; ICC; IP.
PAS516Ca01 Polyclonal Antibody to B-Lymphoid Tyrosine Kinase (BLK) WB; IHC; ICC; IF.
Assay Kits CLS516Ca01 CLIA Kit for B-Lymphoid Tyrosine Kinase (BLK) CLIA assay for Antigen Detection
ELS516Ca01 ELISA Kit for B-Lymphoid Tyrosine Kinase (BLK) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS516Po01 Recombinant B-Lymphoid Tyrosine Kinase (BLK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS516Po01 Monoclonal Antibody to B-Lymphoid Tyrosine Kinase (BLK) WB; IHC; ICC; IP.
PAS516Po01 Polyclonal Antibody to B-Lymphoid Tyrosine Kinase (BLK) WB; IHC; ICC; IF.
Assay Kits CLS516Po01 CLIA Kit for B-Lymphoid Tyrosine Kinase (BLK) CLIA assay for Antigen Detection
ELS516Po01 ELISA Kit for B-Lymphoid Tyrosine Kinase (BLK) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS516Bo01 Recombinant B-Lymphoid Tyrosine Kinase (BLK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS516Bo01 Monoclonal Antibody to B-Lymphoid Tyrosine Kinase (BLK) WB; IHC; ICC; IP.
PAS516Bo01 Polyclonal Antibody to B-Lymphoid Tyrosine Kinase (BLK) WB; IHC; ICC; IF.
Assay Kits CLS516Bo01 CLIA Kit for B-Lymphoid Tyrosine Kinase (BLK) CLIA assay for Antigen Detection
ELS516Bo01 ELISA Kit for B-Lymphoid Tyrosine Kinase (BLK) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS516Rb01 Recombinant B-Lymphoid Tyrosine Kinase (BLK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS516Rb01 Monoclonal Antibody to B-Lymphoid Tyrosine Kinase (BLK) WB; IHC; ICC; IP.
PAS516Rb01 Polyclonal Antibody to B-Lymphoid Tyrosine Kinase (BLK) WB; IHC; ICC; IF.
Assay Kits CLS516Rb01 CLIA Kit for B-Lymphoid Tyrosine Kinase (BLK) CLIA assay for Antigen Detection
ELS516Rb01 ELISA Kit for B-Lymphoid Tyrosine Kinase (BLK) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS516Mo01 Recombinant B-Lymphoid Tyrosine Kinase (BLK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS516Mo01 Monoclonal Antibody to B-Lymphoid Tyrosine Kinase (BLK) WB; IHC; ICC; IP.
PAS516Mo01 Polyclonal Antibody to B-Lymphoid Tyrosine Kinase (BLK) WB; IHC; ICC; IF.
Assay Kits CLS516Mo01 CLIA Kit for B-Lymphoid Tyrosine Kinase (BLK) CLIA assay for Antigen Detection
ELS516Mo01 ELISA Kit for B-Lymphoid Tyrosine Kinase (BLK) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk."
J. Immunol. 154:1265-1272(1995) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk)."
Oncogene 10:477-486(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor."
J. Biol. Chem. 269:22921-22924(1994) [PubMed] [Europe PMC] [Abstract]

"In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation."
Mol. Cell. Biol. 16:4735-4743(1996) [PubMed] [Europe PMC] [Abstract]

"Early B cell factor is an activator of the B lymphoid kinase promoter in early B cell development."
J. Immunol. 163:5453-5461(1999) [PubMed] [Europe PMC] [Abstract]

"IgA Fc receptor (FcalphaR) cross-linking recruits tyrosine kinases, phosphoinositide kinases and serine/threonine kinases to glycolipid rafts."
Biochem. J. 364:517-525(2002) [PubMed] [Europe PMC] [Abstract]

"Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction."
Proc. Natl. Acad. Sci. U.S.A. 106:14460-14465(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]