Rho GDP Dissociation Inhibitor Beta (ARHGDIb)

D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1; RhoGDI2

SPN	S454
HGNC	679
MGI	101940
PubMed	21936715
RGD	1305383
UniProt	P52566
Wiki	ARHGDIB

Members of the Rho (or ARH) protein family and other Ras-related small GTP-binding proteins are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs); guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs decrease the rate of GDP dissociation from Ras-like GTPases. ARHGDIB was expressed abundantly in lung, and at lower levels in several other tissues. Overexpression of ARHGDIB in mammalian cells caused them to 'round up' and disrupted the actin cytoskeleton, mimicking the phenotypic changes associated with inactivation of Rho proteins.

Reference

"Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes."
Proc. Natl. Acad. Sci. U.S.A. 90:7568-7572(1993) [PubMed] [Europe PMC] [Abstract]

"Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton."
Exp. Cell Res. 209:165-174(1993) [PubMed] [Europe PMC] [Abstract]

"cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins."
Proc. Natl. Acad. Sci. U.S.A. 90:1479-1483(1993) [PubMed] [Europe PMC] [Abstract]

"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

, Submitted (MAY-2006) to UniProtKB

"Sequence analysis of proteins separated by polyacrylamide gel electrophoresis: towards an integrated protein database."
Electrophoresis 11:517-527(1990) [PubMed] [Europe PMC] [Abstract]

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1."
Nat. Cell Biol. 12:477-483(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI."
Nat. Struct. Biol. 7:122-126(2000) [PubMed] [Europe PMC] [Abstract]