Excitatory Amino Acid Transporter 3 (EAAT3)
SLC1A1; EAAC1; Solute Carrier 1 Member 1; Sodium-dependent glutamate/aspartate transporter 3; Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter
- SLC1A1 encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect.
- Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers).
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS448Hu01 | Recombinant Excitatory Amino Acid Transporter 3 (EAAT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS448Hu01 | Monoclonal Antibody to Excitatory Amino Acid Transporter 3 (EAAT3) | WB; IHC; ICC; IP. |
| PAS448Hu01 | Polyclonal Antibody to Excitatory Amino Acid Transporter 3 (EAAT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS448Hu01 | CLIA Kit for Excitatory Amino Acid Transporter 3 (EAAT3) | CLIA assay for Antigen Detection |
| ELS448Hu01 | ELISA Kit for Excitatory Amino Acid Transporter 3 (EAAT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS448Mu01 | Recombinant Excitatory Amino Acid Transporter 3 (EAAT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS448Mu01 | Monoclonal Antibody to Excitatory Amino Acid Transporter 3 (EAAT3) | WB; IHC; ICC; IP. |
| PAS448Mu01 | Polyclonal Antibody to Excitatory Amino Acid Transporter 3 (EAAT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS448Mu01 | CLIA Kit for Excitatory Amino Acid Transporter 3 (EAAT3) | CLIA assay for Antigen Detection |
| ELS448Mu01 | ELISA Kit for Excitatory Amino Acid Transporter 3 (EAAT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS448Ra01 | Recombinant Excitatory Amino Acid Transporter 3 (EAAT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS448Ra01 | Monoclonal Antibody to Excitatory Amino Acid Transporter 3 (EAAT3) | WB; IHC; ICC; IP. |
| PAS448Ra01 | Polyclonal Antibody to Excitatory Amino Acid Transporter 3 (EAAT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS448Ra01 | CLIA Kit for Excitatory Amino Acid Transporter 3 (EAAT3) | CLIA assay for Antigen Detection |
| ELS448Ra01 | ELISA Kit for Excitatory Amino Acid Transporter 3 (EAAT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS448Ca01 | Recombinant Excitatory Amino Acid Transporter 3 (EAAT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS448Ca01 | Monoclonal Antibody to Excitatory Amino Acid Transporter 3 (EAAT3) | WB; IHC; ICC; IP. |
| PAS448Ca01 | Polyclonal Antibody to Excitatory Amino Acid Transporter 3 (EAAT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS448Ca01 | CLIA Kit for Excitatory Amino Acid Transporter 3 (EAAT3) | CLIA assay for Antigen Detection |
| ELS448Ca01 | ELISA Kit for Excitatory Amino Acid Transporter 3 (EAAT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS448Po01 | Recombinant Excitatory Amino Acid Transporter 3 (EAAT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS448Po01 | Monoclonal Antibody to Excitatory Amino Acid Transporter 3 (EAAT3) | WB; IHC; ICC; IP. |
| PAS448Po01 | Polyclonal Antibody to Excitatory Amino Acid Transporter 3 (EAAT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS448Po01 | CLIA Kit for Excitatory Amino Acid Transporter 3 (EAAT3) | CLIA assay for Antigen Detection |
| ELS448Po01 | ELISA Kit for Excitatory Amino Acid Transporter 3 (EAAT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS448Bo01 | Recombinant Excitatory Amino Acid Transporter 3 (EAAT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS448Bo01 | Monoclonal Antibody to Excitatory Amino Acid Transporter 3 (EAAT3) | WB; IHC; ICC; IP. |
| PAS448Bo01 | Polyclonal Antibody to Excitatory Amino Acid Transporter 3 (EAAT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS448Bo01 | CLIA Kit for Excitatory Amino Acid Transporter 3 (EAAT3) | CLIA assay for Antigen Detection |
| ELS448Bo01 | ELISA Kit for Excitatory Amino Acid Transporter 3 (EAAT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS448Rb01 | Recombinant Excitatory Amino Acid Transporter 3 (EAAT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS448Rb01 | Monoclonal Antibody to Excitatory Amino Acid Transporter 3 (EAAT3) | WB; IHC; ICC; IP. |
| PAS448Rb01 | Polyclonal Antibody to Excitatory Amino Acid Transporter 3 (EAAT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS448Rb01 | CLIA Kit for Excitatory Amino Acid Transporter 3 (EAAT3) | CLIA assay for Antigen Detection |
| ELS448Rb01 | ELISA Kit for Excitatory Amino Acid Transporter 3 (EAAT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS448Mo01 | Recombinant Excitatory Amino Acid Transporter 3 (EAAT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS448Mo01 | Monoclonal Antibody to Excitatory Amino Acid Transporter 3 (EAAT3) | WB; IHC; ICC; IP. |
| PAS448Mo01 | Polyclonal Antibody to Excitatory Amino Acid Transporter 3 (EAAT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS448Mo01 | CLIA Kit for Excitatory Amino Acid Transporter 3 (EAAT3) | CLIA assay for Antigen Detection |
| ELS448Mo01 | ELISA Kit for Excitatory Amino Acid Transporter 3 (EAAT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain."
Brain Res. 662:245-250(1994) [PubMed] [Europe PMC] [Abstract]
"The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport."
J. Biol. Chem. 269:20599-20606(1994) [PubMed] [Europe PMC] [Abstract]
"Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex."
J. Neurosci. 14:5559-5569(1994) [PubMed] [Europe PMC] [Abstract]
"Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder."
Mol. Psychiatry 6:160-167(2001) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Copy number variants for schizophrenia and related psychotic disorders in Oceanic Palau: risk and transmission in extended pedigrees."
Biol. Psychiatry 70:1115-1121(2011) [PubMed] [Europe PMC] [Abstract]
"Deletion at the SLC1A1 glutamate transporter gene co-segregates with schizophrenia and bipolar schizoaffective disorder in a 5-generation family."
Am. J. Med. Genet. B Neuropsychiatr. Genet. 162B:87-95(2013) [PubMed] [Europe PMC] [Abstract]
"Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria."
J. Clin. Invest. 121:446-453(2011) [PubMed] [Europe PMC] [Abstract]