Vesicular Monoamine Transporter 2 (VMAT2)

SLC18A2; SVMT; SVAT; Solute Carrier Family 18 Member 2,Vesicular Monoamine; Monoamine transporter; Synaptic vesicular amine transporter

SPN	S408
HGNC	10935
MGI	106677
PubMed	24316738
RGD	3694
UniProt	Q05940
Wiki	VMAT2

VMAT2 is an integral membrane protein that acts to transport monoamines—particularly neurotransmitters such as dopamine, norepinephrine, serotonin, and histamine—from cellular cytosol into synaptic vesicles. In humans, the VMAT2 protein is encoded by the VMAT2 gene. Geneticist Dean Hamer identified the VMAT2 gene as correlating with spirituality using data from a smoking survey, which included questions intended to measure "self-transcendence". Hamer performed the spirituality study on the side, independently of the National Cancer Institute smoking study. His findings were published in the mass-market book According to Carl Zimmer, Hamer's study has not been academically published and depends on minor statistical variance.

Reference

"A human synaptic vesicle monoamine transporter cDNA predicts posttranslational modifications, reveals chromosome 10 gene localization and identifies TaqI RFLPs."
FEBS Lett. 318:325-330(1993) [PubMed] [Europe PMC] [Abstract]

"Functional identification and molecular cloning of a human brain vesicle monoamine transporter."
J. Neurochem. 61:2314-2317(1993) [PubMed] [Europe PMC] [Abstract]

"Chromosomal localization of the human vesicular amine transporter genes."
Genomics 18:720-723(1993) [PubMed] [Europe PMC] [Abstract]

"Extensive sequence divergence between the human and rat brain vesicular monoamine transporter: possible molecular basis for species differences in the susceptibility to MPP+."
J. Neural Transm. 93:75-82(1993) [PubMed] [Europe PMC] [Abstract]

"Exon/intron boundaries, novel polymorphisms, and association analysis with schizophrenia of the human synaptic vesicle monoamine transporter (SVMT) gene."
Mol. Psychiatry 6:456-460(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of human vesicle monoamine transporter (VMAT2) lumenal cysteines that form an intramolecular disulfide bond."
Biochemistry 41:6346-6353(2002) [PubMed] [Europe PMC] [Abstract]

"Phosphoproteome of resting human platelets."
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]