Solute Carrier Family 22, Member 11 (SLC22A11)
OAT4; hOAT4; Organic Anion/Urate Transporter 11; Organic anion transporter 4
SLC22A11 is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus.OAT4 also mediated transport of ochratoxin A. OAT4-mediated transport of estrone sulfate was inhibited by several sulfate conjugates. In contrast, glucuronide conjugates showed little or no inhibitory effect on the OAT-mediated transport of estrone sulfate. Cha et al. (2000) demonstrated that OAT4 interacted with chemically heterogeneous anionic compounds, such as nonsteroidal antiinflammatory drugs, diuretics, sulfobromophthalein, penicillin G, and bile salts, whereas it did not interact with tetraethylammonium, an organic cation.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS351Hu01 | Recombinant Solute Carrier Family 22, Member 11 (SLC22A11) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS351Hu01 | Monoclonal Antibody to Solute Carrier Family 22, Member 11 (SLC22A11) | WB; IHC; ICC; IP. |
| PAS351Hu01 | Polyclonal Antibody to Solute Carrier Family 22, Member 11 (SLC22A11) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS351Hu01 | CLIA Kit for Solute Carrier Family 22, Member 11 (SLC22A11) | CLIA assay for Antigen Detection |
| ELS351Hu01 | ELISA Kit for Solute Carrier Family 22, Member 11 (SLC22A11) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS351Mu01 | Recombinant Solute Carrier Family 22, Member 11 (SLC22A11) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS351Mu01 | Monoclonal Antibody to Solute Carrier Family 22, Member 11 (SLC22A11) | WB; IHC; ICC; IP. |
| PAS351Mu01 | Polyclonal Antibody to Solute Carrier Family 22, Member 11 (SLC22A11) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS351Mu01 | CLIA Kit for Solute Carrier Family 22, Member 11 (SLC22A11) | CLIA assay for Antigen Detection |
| ELS351Mu01 | ELISA Kit for Solute Carrier Family 22, Member 11 (SLC22A11) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS351Ra01 | Recombinant Solute Carrier Family 22, Member 11 (SLC22A11) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS351Ra01 | Monoclonal Antibody to Solute Carrier Family 22, Member 11 (SLC22A11) | WB; IHC; ICC; IP. |
| PAS351Ra01 | Polyclonal Antibody to Solute Carrier Family 22, Member 11 (SLC22A11) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS351Ra01 | CLIA Kit for Solute Carrier Family 22, Member 11 (SLC22A11) | CLIA assay for Antigen Detection |
| ELS351Ra01 | ELISA Kit for Solute Carrier Family 22, Member 11 (SLC22A11) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS351Ca01 | Recombinant Solute Carrier Family 22, Member 11 (SLC22A11) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS351Ca01 | Monoclonal Antibody to Solute Carrier Family 22, Member 11 (SLC22A11) | WB; IHC; ICC; IP. |
| PAS351Ca01 | Polyclonal Antibody to Solute Carrier Family 22, Member 11 (SLC22A11) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS351Ca01 | CLIA Kit for Solute Carrier Family 22, Member 11 (SLC22A11) | CLIA assay for Antigen Detection |
| ELS351Ca01 | ELISA Kit for Solute Carrier Family 22, Member 11 (SLC22A11) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS351Po01 | Recombinant Solute Carrier Family 22, Member 11 (SLC22A11) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS351Po01 | Monoclonal Antibody to Solute Carrier Family 22, Member 11 (SLC22A11) | WB; IHC; ICC; IP. |
| PAS351Po01 | Polyclonal Antibody to Solute Carrier Family 22, Member 11 (SLC22A11) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS351Po01 | CLIA Kit for Solute Carrier Family 22, Member 11 (SLC22A11) | CLIA assay for Antigen Detection |
| ELS351Po01 | ELISA Kit for Solute Carrier Family 22, Member 11 (SLC22A11) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS351Bo01 | Recombinant Solute Carrier Family 22, Member 11 (SLC22A11) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS351Bo01 | Monoclonal Antibody to Solute Carrier Family 22, Member 11 (SLC22A11) | WB; IHC; ICC; IP. |
| PAS351Bo01 | Polyclonal Antibody to Solute Carrier Family 22, Member 11 (SLC22A11) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS351Bo01 | CLIA Kit for Solute Carrier Family 22, Member 11 (SLC22A11) | CLIA assay for Antigen Detection |
| ELS351Bo01 | ELISA Kit for Solute Carrier Family 22, Member 11 (SLC22A11) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS351Rb01 | Recombinant Solute Carrier Family 22, Member 11 (SLC22A11) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS351Rb01 | Monoclonal Antibody to Solute Carrier Family 22, Member 11 (SLC22A11) | WB; IHC; ICC; IP. |
| PAS351Rb01 | Polyclonal Antibody to Solute Carrier Family 22, Member 11 (SLC22A11) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS351Rb01 | CLIA Kit for Solute Carrier Family 22, Member 11 (SLC22A11) | CLIA assay for Antigen Detection |
| ELS351Rb01 | ELISA Kit for Solute Carrier Family 22, Member 11 (SLC22A11) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS351Mo01 | Recombinant Solute Carrier Family 22, Member 11 (SLC22A11) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS351Mo01 | Monoclonal Antibody to Solute Carrier Family 22, Member 11 (SLC22A11) | WB; IHC; ICC; IP. |
| PAS351Mo01 | Polyclonal Antibody to Solute Carrier Family 22, Member 11 (SLC22A11) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS351Mo01 | CLIA Kit for Solute Carrier Family 22, Member 11 (SLC22A11) | CLIA assay for Antigen Detection |
| ELS351Mo01 | ELISA Kit for Solute Carrier Family 22, Member 11 (SLC22A11) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta."
J. Biol. Chem. 275:4507-4512(2000) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4)."
Biochem. J. 384:87-92(2004) [PubMed] [Europe PMC] [Abstract]
"The role of glycine residues in the function of human organic anion transporter 4."
Mol. Pharmacol. 65:1141-1147(2004) [PubMed] [Europe PMC] [Abstract]
"The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4."
Mol. Pharmacol. 67:868-876(2005) [PubMed] [Europe PMC] [Abstract]