Solute Carrier Family 25, Member 39 (SLC25A39)

CGI-69

SPN	S344
HGNC	24279
MGI	1196386
PubMed	19656490
RGD	1306193
UniProt	Q9BZJ4
Wiki	SLC25A39

SLC25A39 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006). By searching databases for SLC25 family members, Haitina et al. (2006) identified 2 splice variants of SLC25A39. The deduced protein contains 318 amino acids. Heme biosynthesis consists of a series of eight enzymatic reactions that originate in mitochondria and continue in the cytosol before returning to mitochondria. Although these core enzymes are well studied, additional mitochondrial transporters and regulatory factors are predicted to be required. Moreover, silencing of Slc25a39 in murine erythroleukemia cells impaired iron incorporation into protoporphyrin IX, and vertebrate Slc25a39 complemented an iron homeostasis defect in the orthologous yeast mtm1Delta deletion mutant.

Reference

"Overexpression of the human 2-oxoglutarate carrier lowers mitochondrial membrane potential in HEK-293 cells: contrast with the unique cold-induced mitochondrial carrier CGI-69."
Biochem. J. 353:369-375(2001) [PubMed] [Europe PMC] [Abstract]

"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]

"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing."
EMBO Rep. 1:287-292(2000) [PubMed] [Europe PMC] [Abstract]