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Solute Carrier Family 39, Member 4 (SLC39A4)

ZIP4; AEZ; Acrodermatitis Enteropathica,Zinc-Deficiency Type; Zinc Transporter Protein 4; Zinc transporter ZIP4; Zrt-and Irt-like protein 4

SLC39A4 gene as a candidate intestinal zinc-specific transporter within the susceptibility locus for the zinc-deficiency type of acrodermatitis enteropathica (AEZ) on 8q24.3. The gene is expressed as an mRNA of 2.5 kb in only a few tissues, i.e., kidney, colon, duodenum and jejunum. The duodenum and jejunum are crucial sites of zinc absorption. These transcripts encode proteins of 647 and 622 amino acids sharing the same C-terminal 583 residues. Computational analysis predicted that the larger protein has a cytoplasmic membrane location and a secondary structure characteristic of a ZIP protein, consisting of 8 transmembrane domains organized in 2 blocks of 3 and 5, respectively. These 2 blocks are separated by a variable intracytoplasmic metal-binding site.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS317Hu01 Recombinant Solute Carrier Family 39, Member 4 (SLC39A4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS317Hu01 Monoclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) WB; IHC; ICC; IP.
PAS317Hu01 Polyclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) WB; IHC; ICC; IF.
Assay Kits CLS317Hu01 CLIA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) CLIA assay for Antigen Detection
ELS317Hu01 ELISA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS317Mu01 Recombinant Solute Carrier Family 39, Member 4 (SLC39A4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS317Mu01 Monoclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) WB; IHC; ICC; IP.
PAS317Mu01 Polyclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) WB; IHC; ICC; IF.
Assay Kits CLS317Mu01 CLIA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) CLIA assay for Antigen Detection
ELS317Mu01 ELISA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS317Ra01 Recombinant Solute Carrier Family 39, Member 4 (SLC39A4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS317Ra01 Monoclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) WB; IHC; ICC; IP.
PAS317Ra01 Polyclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) WB; IHC; ICC; IF.
Assay Kits CLS317Ra01 CLIA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) CLIA assay for Antigen Detection
ELS317Ra01 ELISA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS317Ca01 Recombinant Solute Carrier Family 39, Member 4 (SLC39A4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS317Ca01 Monoclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) WB; IHC; ICC; IP.
PAS317Ca01 Polyclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) WB; IHC; ICC; IF.
Assay Kits CLS317Ca01 CLIA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) CLIA assay for Antigen Detection
ELS317Ca01 ELISA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS317Po01 Recombinant Solute Carrier Family 39, Member 4 (SLC39A4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS317Po01 Monoclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) WB; IHC; ICC; IP.
PAS317Po01 Polyclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) WB; IHC; ICC; IF.
Assay Kits CLS317Po01 CLIA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) CLIA assay for Antigen Detection
ELS317Po01 ELISA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS317Bo01 Recombinant Solute Carrier Family 39, Member 4 (SLC39A4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS317Bo01 Monoclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) WB; IHC; ICC; IP.
PAS317Bo01 Polyclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) WB; IHC; ICC; IF.
Assay Kits CLS317Bo01 CLIA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) CLIA assay for Antigen Detection
ELS317Bo01 ELISA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS317Rb01 Recombinant Solute Carrier Family 39, Member 4 (SLC39A4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS317Rb01 Monoclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) WB; IHC; ICC; IP.
PAS317Rb01 Polyclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) WB; IHC; ICC; IF.
Assay Kits CLS317Rb01 CLIA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) CLIA assay for Antigen Detection
ELS317Rb01 ELISA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS317Mo01 Recombinant Solute Carrier Family 39, Member 4 (SLC39A4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS317Mo01 Monoclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) WB; IHC; ICC; IP.
PAS317Mo01 Polyclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) WB; IHC; ICC; IF.
Assay Kits CLS317Mo01 CLIA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) CLIA assay for Antigen Detection
ELS317Mo01 ELISA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Identification of SLC39A4, a gene involved in acrodermatitis enteropathica."
Nat. Genet. 31:239-240(2002) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A novel member of a zinc transporter family is defective in acrodermatitis enteropathica."
Am. J. Hum. Genet. 71:66-73(2002) [PubMed] [Europe PMC] [Abstract]

"Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane."
J. Biol. Chem. 279:4523-4530(2004) [PubMed] [Europe PMC] [Abstract]

"Novel SLC39A4 mutations in acrodermatitis enteropathica."
J. Invest. Dermatol. 120:963-966(2003) [PubMed] [Europe PMC] [Abstract]