Copper Transporter 1 (COPT1)
SLC31A1; CTR1; hCTR1; High Affinity Copper Uptake Protein 1; Solute Carrier Family 31 Member 1
Copper is an element essential for life, but excessive copper can be toxic or even lethal to the cell. Therefore, cells have developed sophisticated ways to maintain a critical copper balance, with the intake, export, and intracellular compartmentalization or buffering of copper strictly regulated.The deduced 190-amino acid human CTR1 protein is similar to yeast CTR1 and Arabidopsis COPT1, a copper transporter also isolated by functional complementation of yeast ctr1. All 3 predicted proteins have 3 transmembrane domains and an N terminus that is rich in methionine and serine residues; the N terminus of human CTR1 is also abundant in histidines. Northern blot analysis detected 2 major CTR1 transcripts of approximately 2 kb and 5.5 kb and a less abundant transcript of about 8.5 kb in all human organs and tissues examined.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS308Hu01 | Recombinant Copper Transporter 1 (COPT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS308Hu01 | Monoclonal Antibody to Copper Transporter 1 (COPT1) | WB; IHC; ICC; IP. |
| PAS308Hu01 | Polyclonal Antibody to Copper Transporter 1 (COPT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS308Hu01 | CLIA Kit for Copper Transporter 1 (COPT1) | CLIA assay for Antigen Detection |
| ELS308Hu01 | ELISA Kit for Copper Transporter 1 (COPT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS308Mu01 | Recombinant Copper Transporter 1 (COPT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS308Mu01 | Monoclonal Antibody to Copper Transporter 1 (COPT1) | WB; IHC; ICC; IP. |
| PAS308Mu01 | Polyclonal Antibody to Copper Transporter 1 (COPT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS308Mu01 | CLIA Kit for Copper Transporter 1 (COPT1) | CLIA assay for Antigen Detection |
| ELS308Mu01 | ELISA Kit for Copper Transporter 1 (COPT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS308Ra01 | Recombinant Copper Transporter 1 (COPT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS308Ra01 | Monoclonal Antibody to Copper Transporter 1 (COPT1) | WB; IHC; ICC; IP. |
| PAS308Ra01 | Polyclonal Antibody to Copper Transporter 1 (COPT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS308Ra01 | CLIA Kit for Copper Transporter 1 (COPT1) | CLIA assay for Antigen Detection |
| ELS308Ra01 | ELISA Kit for Copper Transporter 1 (COPT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS308Ca01 | Recombinant Copper Transporter 1 (COPT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS308Ca01 | Monoclonal Antibody to Copper Transporter 1 (COPT1) | WB; IHC; ICC; IP. |
| PAS308Ca01 | Polyclonal Antibody to Copper Transporter 1 (COPT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS308Ca01 | CLIA Kit for Copper Transporter 1 (COPT1) | CLIA assay for Antigen Detection |
| ELS308Ca01 | ELISA Kit for Copper Transporter 1 (COPT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS308Po01 | Recombinant Copper Transporter 1 (COPT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS308Po01 | Monoclonal Antibody to Copper Transporter 1 (COPT1) | WB; IHC; ICC; IP. |
| PAS308Po01 | Polyclonal Antibody to Copper Transporter 1 (COPT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS308Po01 | CLIA Kit for Copper Transporter 1 (COPT1) | CLIA assay for Antigen Detection |
| ELS308Po01 | ELISA Kit for Copper Transporter 1 (COPT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS308Bo01 | Recombinant Copper Transporter 1 (COPT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS308Bo01 | Monoclonal Antibody to Copper Transporter 1 (COPT1) | WB; IHC; ICC; IP. |
| PAS308Bo01 | Polyclonal Antibody to Copper Transporter 1 (COPT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS308Bo01 | CLIA Kit for Copper Transporter 1 (COPT1) | CLIA assay for Antigen Detection |
| ELS308Bo01 | ELISA Kit for Copper Transporter 1 (COPT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS308Rb01 | Recombinant Copper Transporter 1 (COPT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS308Rb01 | Monoclonal Antibody to Copper Transporter 1 (COPT1) | WB; IHC; ICC; IP. |
| PAS308Rb01 | Polyclonal Antibody to Copper Transporter 1 (COPT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS308Rb01 | CLIA Kit for Copper Transporter 1 (COPT1) | CLIA assay for Antigen Detection |
| ELS308Rb01 | ELISA Kit for Copper Transporter 1 (COPT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS308Mo01 | Recombinant Copper Transporter 1 (COPT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS308Mo01 | Monoclonal Antibody to Copper Transporter 1 (COPT1) | WB; IHC; ICC; IP. |
| PAS308Mo01 | Polyclonal Antibody to Copper Transporter 1 (COPT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS308Mo01 | CLIA Kit for Copper Transporter 1 (COPT1) | CLIA assay for Antigen Detection |
| ELS308Mo01 | ELISA Kit for Copper Transporter 1 (COPT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"hCTR1: a human gene for copper uptake identified by complementation in yeast."
Proc. Natl. Acad. Sci. U.S.A. 94:7481-7486(1997) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Biochemical characterization of the human copper transporter Ctr1."
J. Biol. Chem. 277:4380-4387(2002) [PubMed] [Europe PMC] [Abstract]
"O-linked glycosylation at threonine 27 protects the copper transporter hCTR1 from proteolytic cleavage in mammalian cells."
J. Biol. Chem. 282:20376-20387(2007) [PubMed] [Europe PMC] [Abstract]
"Projection structure of the human copper transporter CTR1 at 6-A resolution reveals a compact trimer with a novel channel-like architecture."
Proc. Natl. Acad. Sci. U.S.A. 103:3627-3632(2006) [PubMed] [Europe PMC] [Abstract]