TATA Box Binding Protein Associated Factor 12 (TAF12)

TAF2J; TAFII20; Transcription Initiation Factor TFIID Subunit 12; Transcription initiation factor TFIID 20/15 kDa subunits

SPN	S239
HGNC	11545
MGI	1913714
PubMed	15735663
RGD	1592841
UniProt	Q16514
Wiki	TAF12

Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS239Hu01	Recombinant TATA Box Binding Protein Associated Factor 12 (TAF12)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS239Hu01	Monoclonal Antibody to TATA Box Binding Protein Associated Factor 12 (TAF12)	WB; IHC; ICC; IP.
Antibodies	PAS239Hu01	Polyclonal Antibody to TATA Box Binding Protein Associated Factor 12 (TAF12)	WB; IHC; ICC; IF.
Assay Kits	CLS239Hu01	CLIA Kit for TATA Box Binding Protein Associated Factor 12 (TAF12)	CLIA assay for Antigen Detection
Assay Kits	ELS239Hu01	ELISA Kit for TATA Box Binding Protein Associated Factor 12 (TAF12)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS239Mu01	Recombinant TATA Box Binding Protein Associated Factor 12 (TAF12)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS239Mu01	Monoclonal Antibody to TATA Box Binding Protein Associated Factor 12 (TAF12)	WB; IHC; ICC; IP.
Antibodies	PAS239Mu01	Polyclonal Antibody to TATA Box Binding Protein Associated Factor 12 (TAF12)	WB; IHC; ICC; IF.
Assay Kits	CLS239Mu01	CLIA Kit for TATA Box Binding Protein Associated Factor 12 (TAF12)	CLIA assay for Antigen Detection
Assay Kits	ELS239Mu01	ELISA Kit for TATA Box Binding Protein Associated Factor 12 (TAF12)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS239Ra01	Recombinant TATA Box Binding Protein Associated Factor 12 (TAF12)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS239Ra01	Monoclonal Antibody to TATA Box Binding Protein Associated Factor 12 (TAF12)	WB; IHC; ICC; IP.
Antibodies	PAS239Ra01	Polyclonal Antibody to TATA Box Binding Protein Associated Factor 12 (TAF12)	WB; IHC; ICC; IF.
Assay Kits	CLS239Ra01	CLIA Kit for TATA Box Binding Protein Associated Factor 12 (TAF12)	CLIA assay for Antigen Detection
Assay Kits	ELS239Ra01	ELISA Kit for TATA Box Binding Protein Associated Factor 12 (TAF12)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS239Ca01	Recombinant TATA Box Binding Protein Associated Factor 12 (TAF12)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS239Ca01	Monoclonal Antibody to TATA Box Binding Protein Associated Factor 12 (TAF12)	WB; IHC; ICC; IP.
Antibodies	PAS239Ca01	Polyclonal Antibody to TATA Box Binding Protein Associated Factor 12 (TAF12)	WB; IHC; ICC; IF.
Assay Kits	CLS239Ca01	CLIA Kit for TATA Box Binding Protein Associated Factor 12 (TAF12)	CLIA assay for Antigen Detection
Assay Kits	ELS239Ca01	ELISA Kit for TATA Box Binding Protein Associated Factor 12 (TAF12)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS239Po01	Recombinant TATA Box Binding Protein Associated Factor 12 (TAF12)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS239Po01	Monoclonal Antibody to TATA Box Binding Protein Associated Factor 12 (TAF12)	WB; IHC; ICC; IP.
Antibodies	PAS239Po01	Polyclonal Antibody to TATA Box Binding Protein Associated Factor 12 (TAF12)	WB; IHC; ICC; IF.
Assay Kits	CLS239Po01	CLIA Kit for TATA Box Binding Protein Associated Factor 12 (TAF12)	CLIA assay for Antigen Detection
Assay Kits	ELS239Po01	ELISA Kit for TATA Box Binding Protein Associated Factor 12 (TAF12)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS239Bo01	Recombinant TATA Box Binding Protein Associated Factor 12 (TAF12)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS239Bo01	Monoclonal Antibody to TATA Box Binding Protein Associated Factor 12 (TAF12)	WB; IHC; ICC; IP.
Antibodies	PAS239Bo01	Polyclonal Antibody to TATA Box Binding Protein Associated Factor 12 (TAF12)	WB; IHC; ICC; IF.
Assay Kits	CLS239Bo01	CLIA Kit for TATA Box Binding Protein Associated Factor 12 (TAF12)	CLIA assay for Antigen Detection
Assay Kits	ELS239Bo01	ELISA Kit for TATA Box Binding Protein Associated Factor 12 (TAF12)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS239Rb01	Recombinant TATA Box Binding Protein Associated Factor 12 (TAF12)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS239Rb01	Monoclonal Antibody to TATA Box Binding Protein Associated Factor 12 (TAF12)	WB; IHC; ICC; IP.
Antibodies	PAS239Rb01	Polyclonal Antibody to TATA Box Binding Protein Associated Factor 12 (TAF12)	WB; IHC; ICC; IF.
Assay Kits	CLS239Rb01	CLIA Kit for TATA Box Binding Protein Associated Factor 12 (TAF12)	CLIA assay for Antigen Detection
Assay Kits	ELS239Rb01	ELISA Kit for TATA Box Binding Protein Associated Factor 12 (TAF12)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS239Mo01	Recombinant TATA Box Binding Protein Associated Factor 12 (TAF12)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS239Mo01	Monoclonal Antibody to TATA Box Binding Protein Associated Factor 12 (TAF12)	WB; IHC; ICC; IP.
Antibodies	PAS239Mo01	Polyclonal Antibody to TATA Box Binding Protein Associated Factor 12 (TAF12)	WB; IHC; ICC; IF.
Assay Kits	CLS239Mo01	CLIA Kit for TATA Box Binding Protein Associated Factor 12 (TAF12)	CLIA assay for Antigen Detection
Assay Kits	ELS239Mo01	ELISA Kit for TATA Box Binding Protein Associated Factor 12 (TAF12)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"A histone octamer-like structure within TFIID."
Nature 380:356-359(1996) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of human TAF20/15. Multiple interactions suggest a central role in TFIID complex formation."
J. Biol. Chem. 271:18194-18202(1996) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of a cDNA encoding a novel human transcription factor TFIID subunit containing similarities with histones H2B and H3."
Gene 169:263-267(1996) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID."
EMBO J. 14:1520-1531(1995) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Histone-like TAFs within the PCAF histone acetylase complex."
Cell 94:35-44(1998) [PubMed] [Europe PMC] [Abstract]

"Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo."
Mol. Cell. Biol. 21:6782-6795(2001) [PubMed] [Europe PMC] [Abstract]

"The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily."
Mol. Cell 2:869-875(1998) [PubMed] [Europe PMC] [Abstract]

"A functional interaction between ATF7 and TAF12 that is modulated by TAF4."
Oncogene 24:3472-3483(2005) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs."
Mol. Cell. Biol. 20:340-351(2000) [PubMed] [Europe PMC] [Abstract]