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Frizzled Homolog 6 (FZD6)

Hfz6

The FZD6 represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif.
This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS225Hu01 Recombinant Frizzled Homolog 6 (FZD6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS225Hu01 Monoclonal Antibody to Frizzled Homolog 6 (FZD6) WB; IHC; ICC; IP.
PAS225Hu01 Polyclonal Antibody to Frizzled Homolog 6 (FZD6) WB; IHC; ICC; IF.
Assay Kits CLS225Hu01 CLIA Kit for Frizzled Homolog 6 (FZD6) CLIA assay for Antigen Detection
ELS225Hu01 ELISA Kit for Frizzled Homolog 6 (FZD6) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS225Mu01 Recombinant Frizzled Homolog 6 (FZD6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS225Mu01 Monoclonal Antibody to Frizzled Homolog 6 (FZD6) WB; IHC; ICC; IP.
PAS225Mu01 Polyclonal Antibody to Frizzled Homolog 6 (FZD6) WB; IHC; ICC; IF.
Assay Kits CLS225Mu01 CLIA Kit for Frizzled Homolog 6 (FZD6) CLIA assay for Antigen Detection
ELS225Mu01 ELISA Kit for Frizzled Homolog 6 (FZD6) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS225Ra01 Recombinant Frizzled Homolog 6 (FZD6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS225Ra01 Monoclonal Antibody to Frizzled Homolog 6 (FZD6) WB; IHC; ICC; IP.
PAS225Ra01 Polyclonal Antibody to Frizzled Homolog 6 (FZD6) WB; IHC; ICC; IF.
Assay Kits CLS225Ra01 CLIA Kit for Frizzled Homolog 6 (FZD6) CLIA assay for Antigen Detection
ELS225Ra01 ELISA Kit for Frizzled Homolog 6 (FZD6) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS225Ca01 Recombinant Frizzled Homolog 6 (FZD6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS225Ca01 Monoclonal Antibody to Frizzled Homolog 6 (FZD6) WB; IHC; ICC; IP.
PAS225Ca01 Polyclonal Antibody to Frizzled Homolog 6 (FZD6) WB; IHC; ICC; IF.
Assay Kits CLS225Ca01 CLIA Kit for Frizzled Homolog 6 (FZD6) CLIA assay for Antigen Detection
ELS225Ca01 ELISA Kit for Frizzled Homolog 6 (FZD6) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS225Po01 Recombinant Frizzled Homolog 6 (FZD6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS225Po01 Monoclonal Antibody to Frizzled Homolog 6 (FZD6) WB; IHC; ICC; IP.
PAS225Po01 Polyclonal Antibody to Frizzled Homolog 6 (FZD6) WB; IHC; ICC; IF.
Assay Kits CLS225Po01 CLIA Kit for Frizzled Homolog 6 (FZD6) CLIA assay for Antigen Detection
ELS225Po01 ELISA Kit for Frizzled Homolog 6 (FZD6) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS225Bo01 Recombinant Frizzled Homolog 6 (FZD6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS225Bo01 Monoclonal Antibody to Frizzled Homolog 6 (FZD6) WB; IHC; ICC; IP.
PAS225Bo01 Polyclonal Antibody to Frizzled Homolog 6 (FZD6) WB; IHC; ICC; IF.
Assay Kits CLS225Bo01 CLIA Kit for Frizzled Homolog 6 (FZD6) CLIA assay for Antigen Detection
ELS225Bo01 ELISA Kit for Frizzled Homolog 6 (FZD6) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS225Rb01 Recombinant Frizzled Homolog 6 (FZD6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS225Rb01 Monoclonal Antibody to Frizzled Homolog 6 (FZD6) WB; IHC; ICC; IP.
PAS225Rb01 Polyclonal Antibody to Frizzled Homolog 6 (FZD6) WB; IHC; ICC; IF.
Assay Kits CLS225Rb01 CLIA Kit for Frizzled Homolog 6 (FZD6) CLIA assay for Antigen Detection
ELS225Rb01 ELISA Kit for Frizzled Homolog 6 (FZD6) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS225Mo01 Recombinant Frizzled Homolog 6 (FZD6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS225Mo01 Monoclonal Antibody to Frizzled Homolog 6 (FZD6) WB; IHC; ICC; IP.
PAS225Mo01 Polyclonal Antibody to Frizzled Homolog 6 (FZD6) WB; IHC; ICC; IF.
Assay Kits CLS225Mo01 CLIA Kit for Frizzled Homolog 6 (FZD6) CLIA assay for Antigen Detection
ELS225Mo01 ELISA Kit for Frizzled Homolog 6 (FZD6) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning of human frizzled-6."
Biochem. Biophys. Res. Commun. 243:622-627(1998) [PubMed] [Europe PMC] [Abstract]

"BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia."
Proc. Natl. Acad. Sci. U.S.A. 98:13901-13906(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"FZD6 is a novel gene for human neural tube defects."
Hum. Mutat. 33:384-390(2012) [PubMed] [Europe PMC] [Abstract]

"ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner."
Nature 485:195-200(2012) [PubMed] [Europe PMC] [Abstract]

"Mutations in Frizzled 6 cause isolated autosomal-recessive nail dysplasia."
Am. J. Hum. Genet. 88:852-860(2011) [PubMed] [Europe PMC] [Abstract]