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Dihydropyrimidinase Like Protein 2 (DPYSL2)

CRMP2; DHPRP2; DRP-2; DRP2; ULIP2; Unc-33-like phosphoprotein 2; Collapsin response mediator protein 2

The DPYSL2 protein has 572 amino acids. Northern blot analysis detected a 4.9-kb DPYSL2 transcript in all tissues examined except liver.
Expression of the nonphosphorylated form of CRMP2 or inhibition of GSK3-beta induced the formation of multiple axon-like neurites in hippocampal neurons. Expression of constitutively active GSK3-beta impaired neuronal polarization, whereas the nonphosphorylated form of CRMP2 counteracted the inhibitory effects of GSK3-beta, indicating that GSK3-beta regulates neuronal polarity through phosphorylation of CRMP2. Treatment of hippocampal neurons with neurotrophin-3 (NT3) induced inactivation of GSK3-beta and dephosphorylation of CRMP2.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS185Hu01 Recombinant Dihydropyrimidinase Like Protein 2 (DPYSL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS185Hu01 Monoclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) WB; IHC; ICC; IP.
PAS185Hu01 Polyclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) WB; IHC; ICC; IF.
Assay Kits CLS185Hu01 CLIA Kit for Dihydropyrimidinase Like Protein 2 (DPYSL2) CLIA assay for Antigen Detection
ELS185Hu01 ELISA Kit for Dihydropyrimidinase Like Protein 2 (DPYSL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS185Mu01 Recombinant Dihydropyrimidinase Like Protein 2 (DPYSL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS185Mu01 Monoclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) WB; IHC; ICC; IP.
PAS185Mu01 Polyclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) WB; IHC; ICC; IF.
Assay Kits CLS185Mu01 CLIA Kit for Dihydropyrimidinase Like Protein 2 (DPYSL2) CLIA assay for Antigen Detection
ELS185Mu01 ELISA Kit for Dihydropyrimidinase Like Protein 2 (DPYSL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS185Ra01 Recombinant Dihydropyrimidinase Like Protein 2 (DPYSL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS185Ra01 Monoclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) WB; IHC; ICC; IP.
PAS185Ra01 Polyclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) WB; IHC; ICC; IF.
Assay Kits CLS185Ra01 CLIA Kit for Dihydropyrimidinase Like Protein 2 (DPYSL2) CLIA assay for Antigen Detection
ELS185Ra01 ELISA Kit for Dihydropyrimidinase Like Protein 2 (DPYSL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS185Ca01 Recombinant Dihydropyrimidinase Like Protein 2 (DPYSL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS185Ca01 Monoclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) WB; IHC; ICC; IP.
PAS185Ca01 Polyclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) WB; IHC; ICC; IF.
Assay Kits CLS185Ca01 CLIA Kit for Dihydropyrimidinase Like Protein 2 (DPYSL2) CLIA assay for Antigen Detection
ELS185Ca01 ELISA Kit for Dihydropyrimidinase Like Protein 2 (DPYSL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS185Po01 Recombinant Dihydropyrimidinase Like Protein 2 (DPYSL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS185Po01 Monoclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) WB; IHC; ICC; IP.
PAS185Po01 Polyclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) WB; IHC; ICC; IF.
Assay Kits CLS185Po01 CLIA Kit for Dihydropyrimidinase Like Protein 2 (DPYSL2) CLIA assay for Antigen Detection
ELS185Po01 ELISA Kit for Dihydropyrimidinase Like Protein 2 (DPYSL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS185Bo01 Recombinant Dihydropyrimidinase Like Protein 2 (DPYSL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS185Bo01 Monoclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) WB; IHC; ICC; IP.
PAS185Bo01 Polyclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) WB; IHC; ICC; IF.
Assay Kits CLS185Bo01 CLIA Kit for Dihydropyrimidinase Like Protein 2 (DPYSL2) CLIA assay for Antigen Detection
ELS185Bo01 ELISA Kit for Dihydropyrimidinase Like Protein 2 (DPYSL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS185Rb01 Recombinant Dihydropyrimidinase Like Protein 2 (DPYSL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS185Rb01 Monoclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) WB; IHC; ICC; IP.
PAS185Rb01 Polyclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) WB; IHC; ICC; IF.
Assay Kits CLS185Rb01 CLIA Kit for Dihydropyrimidinase Like Protein 2 (DPYSL2) CLIA assay for Antigen Detection
ELS185Rb01 ELISA Kit for Dihydropyrimidinase Like Protein 2 (DPYSL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS185Mo01 Recombinant Dihydropyrimidinase Like Protein 2 (DPYSL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS185Mo01 Monoclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) WB; IHC; ICC; IP.
PAS185Mo01 Polyclonal Antibody to Dihydropyrimidinase Like Protein 2 (DPYSL2) WB; IHC; ICC; IF.
Assay Kits CLS185Mo01 CLIA Kit for Dihydropyrimidinase Like Protein 2 (DPYSL2) CLIA assay for Antigen Detection
ELS185Mo01 ELISA Kit for Dihydropyrimidinase Like Protein 2 (DPYSL2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33."
Nature 376:509-514(1995) [PubMed] [Europe PMC] [Abstract]

"A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution."
Gene 180:157-163(1996) [PubMed] [Europe PMC] [Abstract]

"Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene."
DNA Res. 6:291-297(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

, Submitted (DEC-2008) to UniProtKB

"Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522."
Biochemistry 39:4267-4275(2000) [PubMed] [Europe PMC] [Abstract]

"CRMP-2 induces axons in cultured hippocampal neurons."
Nat. Neurosci. 4:781-782(2001) [PubMed] [Europe PMC] [Abstract]

"GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons."
J. Biol. Chem. 279:50176-50180(2004) [PubMed] [Europe PMC] [Abstract]

"CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation."
Mol. Cell. Biol. 25:9920-9935(2005) [PubMed] [Europe PMC] [Abstract]

"Structural bases for CRMP function in plexin-dependent semaphorin3A signaling."
EMBO J. 23:9-22(2004) [PubMed] [Europe PMC] [Abstract]

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32."
J. Biol. Chem. 284:27393-27401(2009) [PubMed] [Europe PMC] [Abstract]

"Protein product of CLN6 gene responsible for variant late-onset infantile neuronal ceroid lipofuscinosis interacts with CRMP-2."
J. Neurosci. Res. 87:2157-2166(2009) [PubMed] [Europe PMC] [Abstract]

"Collapsin response mediator protein-2 (Crmp2) regulates trafficking by linking endocytic regulatory proteins to dynein motors."
J. Biol. Chem. 285:31918-31922(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Resveratrol-induced changes of the human adipocyte secretion profile."
J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"The structure of human collapsin response mediator protein 2, a regulator of axonal growth."
J. Neurochem. 101:906-917(2007) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]