Cyclin Dependent Kinase Inhibitor 2B (CDKN2B)
p15; INK4B; MTS2; TP15; Cyclin-dependent kinase 4 inhibitor B; Multiple tumor suppressor 2
Cyclin-dependent kinase 4 inhibitor B lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors.
This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases by cyclin D, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS144Hu01 | Recombinant Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS144Hu01 | Monoclonal Antibody to Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | WB; IHC; ICC; IP. |
| PAS144Hu01 | Polyclonal Antibody to Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS144Hu01 | CLIA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | CLIA assay for Antigen Detection |
| ELS144Hu01 | ELISA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS144Mu01 | Recombinant Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS144Mu01 | Monoclonal Antibody to Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | WB; IHC; ICC; IP. |
| PAS144Mu01 | Polyclonal Antibody to Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS144Mu01 | CLIA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | CLIA assay for Antigen Detection |
| ELS144Mu01 | ELISA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS144Ra01 | Recombinant Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS144Ra01 | Monoclonal Antibody to Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | WB; IHC; ICC; IP. |
| PAS144Ra01 | Polyclonal Antibody to Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS144Ra01 | CLIA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | CLIA assay for Antigen Detection |
| ELS144Ra01 | ELISA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS144Ca01 | Recombinant Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS144Ca01 | Monoclonal Antibody to Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | WB; IHC; ICC; IP. |
| PAS144Ca01 | Polyclonal Antibody to Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS144Ca01 | CLIA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | CLIA assay for Antigen Detection |
| ELS144Ca01 | ELISA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS144Po01 | Recombinant Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS144Po01 | Monoclonal Antibody to Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | WB; IHC; ICC; IP. |
| PAS144Po01 | Polyclonal Antibody to Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS144Po01 | CLIA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | CLIA assay for Antigen Detection |
| ELS144Po01 | ELISA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS144Bo01 | Recombinant Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS144Bo01 | Monoclonal Antibody to Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | WB; IHC; ICC; IP. |
| PAS144Bo01 | Polyclonal Antibody to Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS144Bo01 | CLIA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | CLIA assay for Antigen Detection |
| ELS144Bo01 | ELISA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS144Rb01 | Recombinant Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS144Rb01 | Monoclonal Antibody to Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | WB; IHC; ICC; IP. |
| PAS144Rb01 | Polyclonal Antibody to Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS144Rb01 | CLIA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | CLIA assay for Antigen Detection |
| ELS144Rb01 | ELISA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS144Mo01 | Recombinant Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS144Mo01 | Monoclonal Antibody to Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | WB; IHC; ICC; IP. |
| PAS144Mo01 | Polyclonal Antibody to Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS144Mo01 | CLIA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | CLIA assay for Antigen Detection |
| ELS144Mo01 | ELISA Kit for Cyclin Dependent Kinase Inhibitor 2B (CDKN2B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function."
Genes Dev. 8:2939-2952(1994) [PubMed] [Europe PMC] [Abstract]
"p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest."
Nature 371:257-261(1994) [PubMed] [Europe PMC] [Abstract]
"Cloning and characterization of p10, an alternatively spliced form of p15 cyclin-dependent kinase inhibitor."
Cancer Res. 57:2966-2973(1997) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"A cell cycle regulator potentially involved in genesis of many tumor types."
Science 264:436-440(1994) [PubMed] [Europe PMC] [Abstract]
"Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data."
Protein Sci. 9:1120-1128(2000) [PubMed] [Europe PMC] [Abstract]
"Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer."
Cancer Res. 55:1448-1451(1995) [PubMed] [Europe PMC] [Abstract]