Receptor Interacting Serine Threonine Kinase 3 (RIPK3)

RIP3; RIP-like protein kinase 3; Receptor-interacting protein 3

SPN	S132
HGNC	10021
MGI	2154952
PubMed	22814620
RGD	628899
UniProt	Q9Y572
Wiki	RIPK3

Receptor-interacting serine/threonine-protein kinase 3 is is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.

Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.

Reference

"Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB."
Curr. Biol. 9:539-542(1999) [PubMed] [Europe PMC] [Abstract]

"RIP3, a novel apoptosis-inducing kinase."
J. Biol. Chem. 274:16871-16875(1999) [PubMed] [Europe PMC] [Abstract]

"RIP3 beta and RIP3 gamma, two novel splice variants of receptor-interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis."
Biochem. Biophys. Res. Commun. 332:181-187(2005) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 14."
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3."
J. Biol. Chem. 277:9505-9511(2002) [PubMed] [Europe PMC] [Abstract]

"RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis."
Science 325:332-336(2009) [PubMed] [Europe PMC] [Abstract]

"Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha."
Cell 137:1100-1111(2009) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation."
Cell 137:1112-1123(2009) [PubMed] [Europe PMC] [Abstract]

"The role of the kinases RIP1 and RIP3 in TNF-induced necrosis."
Sci. Signal. 3:RE4-RE4(2010) [PubMed] [Europe PMC] [Abstract]

"cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)."
PLoS ONE 6:E22356-E22356(2011) [PubMed] [Europe PMC] [Abstract]

"Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase."
Cell 148:213-227(2012) [PubMed] [Europe PMC] [Abstract]

"The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways."
Cell 148:228-243(2012) [PubMed] [Europe PMC] [Abstract]

"Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1."
Inflamm. Bowel Dis. 18:603-612(2012) [PubMed] [Europe PMC] [Abstract]

"Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis."
Proc. Natl. Acad. Sci. U.S.A. 109:5322-5327(2012) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]