FK506 Binding Protein 1B (FKBP1B)
FKBP12.6; FKBP1L; FKBP9; OTK4; PKBP1L; Rotamase; 12.6 kDa FK506-binding protein; Immunophilin FKBP12.6; Peptidyl-prolyl cis-trans isomerase FKBP1B
FKBP1B is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus). It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms.There are four molecules of FKBP12.6 per heart muscle RYR. Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS129Hu01 | Recombinant FK506 Binding Protein 1B (FKBP1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS129Hu01 | Monoclonal Antibody to FK506 Binding Protein 1B (FKBP1B) | WB; IHC; ICC; IP. |
| PAS129Hu01 | Polyclonal Antibody to FK506 Binding Protein 1B (FKBP1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS129Hu01 | CLIA Kit for FK506 Binding Protein 1B (FKBP1B) | CLIA assay for Antigen Detection |
| ELS129Hu01 | ELISA Kit for FK506 Binding Protein 1B (FKBP1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS129Mu01 | Recombinant FK506 Binding Protein 1B (FKBP1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS129Mu01 | Monoclonal Antibody to FK506 Binding Protein 1B (FKBP1B) | WB; IHC; ICC; IP. |
| PAS129Mu01 | Polyclonal Antibody to FK506 Binding Protein 1B (FKBP1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS129Mu01 | CLIA Kit for FK506 Binding Protein 1B (FKBP1B) | CLIA assay for Antigen Detection |
| ELS129Mu01 | ELISA Kit for FK506 Binding Protein 1B (FKBP1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS129Ra01 | Recombinant FK506 Binding Protein 1B (FKBP1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS129Ra01 | Monoclonal Antibody to FK506 Binding Protein 1B (FKBP1B) | WB; IHC; ICC; IP. |
| PAS129Ra01 | Polyclonal Antibody to FK506 Binding Protein 1B (FKBP1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS129Ra01 | CLIA Kit for FK506 Binding Protein 1B (FKBP1B) | CLIA assay for Antigen Detection |
| ELS129Ra01 | ELISA Kit for FK506 Binding Protein 1B (FKBP1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS129Ca01 | Recombinant FK506 Binding Protein 1B (FKBP1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS129Ca01 | Monoclonal Antibody to FK506 Binding Protein 1B (FKBP1B) | WB; IHC; ICC; IP. |
| PAS129Ca01 | Polyclonal Antibody to FK506 Binding Protein 1B (FKBP1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS129Ca01 | CLIA Kit for FK506 Binding Protein 1B (FKBP1B) | CLIA assay for Antigen Detection |
| ELS129Ca01 | ELISA Kit for FK506 Binding Protein 1B (FKBP1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS129Po01 | Recombinant FK506 Binding Protein 1B (FKBP1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS129Po01 | Monoclonal Antibody to FK506 Binding Protein 1B (FKBP1B) | WB; IHC; ICC; IP. |
| PAS129Po01 | Polyclonal Antibody to FK506 Binding Protein 1B (FKBP1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS129Po01 | CLIA Kit for FK506 Binding Protein 1B (FKBP1B) | CLIA assay for Antigen Detection |
| ELS129Po01 | ELISA Kit for FK506 Binding Protein 1B (FKBP1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS129Bo01 | Recombinant FK506 Binding Protein 1B (FKBP1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS129Bo01 | Monoclonal Antibody to FK506 Binding Protein 1B (FKBP1B) | WB; IHC; ICC; IP. |
| PAS129Bo01 | Polyclonal Antibody to FK506 Binding Protein 1B (FKBP1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS129Bo01 | CLIA Kit for FK506 Binding Protein 1B (FKBP1B) | CLIA assay for Antigen Detection |
| ELS129Bo01 | ELISA Kit for FK506 Binding Protein 1B (FKBP1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS129Rb01 | Recombinant FK506 Binding Protein 1B (FKBP1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS129Rb01 | Monoclonal Antibody to FK506 Binding Protein 1B (FKBP1B) | WB; IHC; ICC; IP. |
| PAS129Rb01 | Polyclonal Antibody to FK506 Binding Protein 1B (FKBP1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS129Rb01 | CLIA Kit for FK506 Binding Protein 1B (FKBP1B) | CLIA assay for Antigen Detection |
| ELS129Rb01 | ELISA Kit for FK506 Binding Protein 1B (FKBP1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS129Mo01 | Recombinant FK506 Binding Protein 1B (FKBP1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS129Mo01 | Monoclonal Antibody to FK506 Binding Protein 1B (FKBP1B) | WB; IHC; ICC; IP. |
| PAS129Mo01 | Polyclonal Antibody to FK506 Binding Protein 1B (FKBP1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS129Mo01 | CLIA Kit for FK506 Binding Protein 1B (FKBP1B) | CLIA assay for Antigen Detection |
| ELS129Mo01 | ELISA Kit for FK506 Binding Protein 1B (FKBP1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts."
Biochem. Biophys. Res. Commun. 200:836-843(1994) [PubMed] [Europe PMC] [Abstract]
"A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor."
J. Biol. Chem. 270:26511-26522(1995) [PubMed] [Europe PMC] [Abstract]
"Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6."
Gene 360:55-64(2005) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts."
Cell 101:365-376(2000) [PubMed] [Europe PMC] [Abstract]
"Structure of FKBP12.6 in complex with rapamycin."
Acta Crystallogr. D 56:266-271(2000) [PubMed] [Europe PMC] [Abstract]