Tubulin Beta 3 (TUBb3)

MC1R; TUBB4; Tubulin beta-4 chain

SPN	S091
HGNC	20772
MGI	107813
PubMed	22684772
RGD	628595
UniProt	Q13509
Wiki	TUBB3

TUBB3 expression in several human cell lines, but not in a paclitaxel-resistant cell line. RNA interference revealed that HIF1A mediated hypoxia-induced TUBB3 expression. Chromatin immunoprecipitation analysis showed that HIF1A bound an HIF1A-binding site in the 5-prime flanking region of the TUBB3 gene. Methylation of an enhancer in the 3-prime flanking region abolished hypoxia-induced TUBB3 expression. Much lower Tubb3 levels were detected in all other adult mouse tissues examined except brain, where expression was even lower. Chromatin immunoprecipitation analysis showed that HIF1A bound an HIF1A-binding site in the 5-prime flanking region of the TUBB3 gene. Methylation of an enhancer in the 3-prime flanking region abolished hypoxia-induced TUBB3 expression.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS091Hu01	Recombinant Tubulin Beta 3 (TUBb3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS091Hu01	Monoclonal Antibody to Tubulin Beta 3 (TUBb3)	WB; IHC; ICC; IP.
Antibodies	PAS091Hu01	Polyclonal Antibody to Tubulin Beta 3 (TUBb3)	WB; IHC; ICC; IF.
Assay Kits	CLS091Hu01	CLIA Kit for Tubulin Beta 3 (TUBb3)	CLIA assay for Antigen Detection
Assay Kits	ELS091Hu01	ELISA Kit for Tubulin Beta 3 (TUBb3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS091Mu01	Recombinant Tubulin Beta 3 (TUBb3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS091Mu01	Monoclonal Antibody to Tubulin Beta 3 (TUBb3)	WB; IHC; ICC; IP.
Antibodies	PAS091Mu01	Polyclonal Antibody to Tubulin Beta 3 (TUBb3)	WB; IHC; ICC; IF.
Assay Kits	CLS091Mu01	CLIA Kit for Tubulin Beta 3 (TUBb3)	CLIA assay for Antigen Detection
Assay Kits	ELS091Mu01	ELISA Kit for Tubulin Beta 3 (TUBb3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS091Ra01	Recombinant Tubulin Beta 3 (TUBb3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS091Ra01	Monoclonal Antibody to Tubulin Beta 3 (TUBb3)	WB; IHC; ICC; IP.
Antibodies	PAS091Ra01	Polyclonal Antibody to Tubulin Beta 3 (TUBb3)	WB; IHC; ICC; IF.
Assay Kits	CLS091Ra01	CLIA Kit for Tubulin Beta 3 (TUBb3)	CLIA assay for Antigen Detection
Assay Kits	ELS091Ra01	ELISA Kit for Tubulin Beta 3 (TUBb3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS091Ca01	Recombinant Tubulin Beta 3 (TUBb3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS091Ca01	Monoclonal Antibody to Tubulin Beta 3 (TUBb3)	WB; IHC; ICC; IP.
Antibodies	PAS091Ca01	Polyclonal Antibody to Tubulin Beta 3 (TUBb3)	WB; IHC; ICC; IF.
Assay Kits	CLS091Ca01	CLIA Kit for Tubulin Beta 3 (TUBb3)	CLIA assay for Antigen Detection
Assay Kits	ELS091Ca01	ELISA Kit for Tubulin Beta 3 (TUBb3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS091Po01	Recombinant Tubulin Beta 3 (TUBb3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS091Po01	Monoclonal Antibody to Tubulin Beta 3 (TUBb3)	WB; IHC; ICC; IP.
Antibodies	PAS091Po01	Polyclonal Antibody to Tubulin Beta 3 (TUBb3)	WB; IHC; ICC; IF.
Assay Kits	CLS091Po01	CLIA Kit for Tubulin Beta 3 (TUBb3)	CLIA assay for Antigen Detection
Assay Kits	ELS091Po01	ELISA Kit for Tubulin Beta 3 (TUBb3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS091Bo01	Recombinant Tubulin Beta 3 (TUBb3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS091Bo01	Monoclonal Antibody to Tubulin Beta 3 (TUBb3)	WB; IHC; ICC; IP.
Antibodies	PAS091Bo01	Polyclonal Antibody to Tubulin Beta 3 (TUBb3)	WB; IHC; ICC; IF.
Assay Kits	CLS091Bo01	CLIA Kit for Tubulin Beta 3 (TUBb3)	CLIA assay for Antigen Detection
Assay Kits	ELS091Bo01	ELISA Kit for Tubulin Beta 3 (TUBb3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS091Rb01	Recombinant Tubulin Beta 3 (TUBb3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS091Rb01	Monoclonal Antibody to Tubulin Beta 3 (TUBb3)	WB; IHC; ICC; IP.
Antibodies	PAS091Rb01	Polyclonal Antibody to Tubulin Beta 3 (TUBb3)	WB; IHC; ICC; IF.
Assay Kits	CLS091Rb01	CLIA Kit for Tubulin Beta 3 (TUBb3)	CLIA assay for Antigen Detection
Assay Kits	ELS091Rb01	ELISA Kit for Tubulin Beta 3 (TUBb3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS091Mo01	Recombinant Tubulin Beta 3 (TUBb3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS091Mo01	Monoclonal Antibody to Tubulin Beta 3 (TUBb3)	WB; IHC; ICC; IP.
Antibodies	PAS091Mo01	Polyclonal Antibody to Tubulin Beta 3 (TUBb3)	WB; IHC; ICC; IF.
Assay Kits	CLS091Mo01	CLIA Kit for Tubulin Beta 3 (TUBb3)	CLIA assay for Antigen Detection
Assay Kits	ELS091Mo01	ELISA Kit for Tubulin Beta 3 (TUBb3)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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Biochim. Biophys. Acta 1395:237-245(1998) [PubMed] [Europe PMC] [Abstract]

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

, Submitted (DEC-2008) to UniProtKB

"Class III beta-tubulin isotype: a key cytoskeletal protein at the crossroads of developmental neurobiology and tumor neuropathology."
J. Child Neurol. 18:851-866(2003) [PubMed] [Europe PMC] [Abstract]

Erratum
J. Child Neurol. 19:531-531(2004)

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Mol. Biol. Cell 17:1041-1050(2006) [PubMed] [Europe PMC] [Abstract]

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J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]

"Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation."
Cell 137:1076-1087(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance."
Cell 140:74-87(2010) [PubMed] [Europe PMC] [Abstract]

"Tumoral and tissue-specific expression of the major human beta-tubulin isotypes."
Cytoskeleton 67:214-223(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Mutations in the neuronal ss-tubulin subunit TUBB3 result in malformation of cortical development and neuronal migration defects."
Hum. Mol. Genet. 19:4462-4473(2010) [PubMed] [Europe PMC] [Abstract]