Tau-Tubulin Kinase 2 (tTBK2)
SCA11; Spinocerebellar Ataxia 11
- TTBK2 produces a 5.6-kb transcript in which the longest open reading frame is 3,732 nucleotides, encoding a protein of 1,244 amino acids. The gene is alternatively spliced, with ubiquitous expression in human adult and fetal tissues. The N-terminus of TTBK2 encodes a serine-threonine-tyrosine kinase domain, and a C-terminal region shows homology to TTBK1. TTBK2 was expressed in all brain regions in human, rat, and mouse tissue. There was particularly high expression in Purkinje cells of the cerebellum, granular cell layer, hippocampus, midbrain, and substantia nigra. Lower expression was seen in the cortex of human, rat, and mouse brains.2 TTBK2 phosphorylation sites in tau (ser208 and ser210) are priming sites for the phosphorylation of tau by GSK-3-beta, which influences tau pathology.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS079Hu01 | Recombinant Tau-Tubulin Kinase 2 (tTBK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS079Hu01 | Monoclonal Antibody to Tau-Tubulin Kinase 2 (tTBK2) | WB; IHC; ICC; IP. |
| PAS079Hu01 | Polyclonal Antibody to Tau-Tubulin Kinase 2 (tTBK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS079Hu01 | CLIA Kit for Tau-Tubulin Kinase 2 (tTBK2) | CLIA assay for Antigen Detection |
| ELS079Hu01 | ELISA Kit for Tau-Tubulin Kinase 2 (tTBK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS079Mu01 | Recombinant Tau-Tubulin Kinase 2 (tTBK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS079Mu01 | Monoclonal Antibody to Tau-Tubulin Kinase 2 (tTBK2) | WB; IHC; ICC; IP. |
| PAS079Mu01 | Polyclonal Antibody to Tau-Tubulin Kinase 2 (tTBK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS079Mu01 | CLIA Kit for Tau-Tubulin Kinase 2 (tTBK2) | CLIA assay for Antigen Detection |
| ELS079Mu01 | ELISA Kit for Tau-Tubulin Kinase 2 (tTBK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS079Ra01 | Recombinant Tau-Tubulin Kinase 2 (tTBK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS079Ra01 | Monoclonal Antibody to Tau-Tubulin Kinase 2 (tTBK2) | WB; IHC; ICC; IP. |
| PAS079Ra01 | Polyclonal Antibody to Tau-Tubulin Kinase 2 (tTBK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS079Ra01 | CLIA Kit for Tau-Tubulin Kinase 2 (tTBK2) | CLIA assay for Antigen Detection |
| ELS079Ra01 | ELISA Kit for Tau-Tubulin Kinase 2 (tTBK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS079Ca01 | Recombinant Tau-Tubulin Kinase 2 (tTBK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS079Ca01 | Monoclonal Antibody to Tau-Tubulin Kinase 2 (tTBK2) | WB; IHC; ICC; IP. |
| PAS079Ca01 | Polyclonal Antibody to Tau-Tubulin Kinase 2 (tTBK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS079Ca01 | CLIA Kit for Tau-Tubulin Kinase 2 (tTBK2) | CLIA assay for Antigen Detection |
| ELS079Ca01 | ELISA Kit for Tau-Tubulin Kinase 2 (tTBK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS079Po01 | Recombinant Tau-Tubulin Kinase 2 (tTBK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS079Po01 | Monoclonal Antibody to Tau-Tubulin Kinase 2 (tTBK2) | WB; IHC; ICC; IP. |
| PAS079Po01 | Polyclonal Antibody to Tau-Tubulin Kinase 2 (tTBK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS079Po01 | CLIA Kit for Tau-Tubulin Kinase 2 (tTBK2) | CLIA assay for Antigen Detection |
| ELS079Po01 | ELISA Kit for Tau-Tubulin Kinase 2 (tTBK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS079Bo01 | Recombinant Tau-Tubulin Kinase 2 (tTBK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS079Bo01 | Monoclonal Antibody to Tau-Tubulin Kinase 2 (tTBK2) | WB; IHC; ICC; IP. |
| PAS079Bo01 | Polyclonal Antibody to Tau-Tubulin Kinase 2 (tTBK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS079Bo01 | CLIA Kit for Tau-Tubulin Kinase 2 (tTBK2) | CLIA assay for Antigen Detection |
| ELS079Bo01 | ELISA Kit for Tau-Tubulin Kinase 2 (tTBK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS079Rb01 | Recombinant Tau-Tubulin Kinase 2 (tTBK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS079Rb01 | Monoclonal Antibody to Tau-Tubulin Kinase 2 (tTBK2) | WB; IHC; ICC; IP. |
| PAS079Rb01 | Polyclonal Antibody to Tau-Tubulin Kinase 2 (tTBK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS079Rb01 | CLIA Kit for Tau-Tubulin Kinase 2 (tTBK2) | CLIA assay for Antigen Detection |
| ELS079Rb01 | ELISA Kit for Tau-Tubulin Kinase 2 (tTBK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS079Mo01 | Recombinant Tau-Tubulin Kinase 2 (tTBK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS079Mo01 | Monoclonal Antibody to Tau-Tubulin Kinase 2 (tTBK2) | WB; IHC; ICC; IP. |
| PAS079Mo01 | Polyclonal Antibody to Tau-Tubulin Kinase 2 (tTBK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS079Mo01 | CLIA Kit for Tau-Tubulin Kinase 2 (tTBK2) | CLIA assay for Antigen Detection |
| ELS079Mo01 | ELISA Kit for Tau-Tubulin Kinase 2 (tTBK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
"Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11."
Nat. Genet. 39:1434-1436(2007) [PubMed] [Europe PMC] [Abstract]
"TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development."
Biochem. J. 437:157-167(2011) [PubMed] [Europe PMC] [Abstract]
"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
"Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling."
Cell 150:533-548(2012) [PubMed] [Europe PMC] [Abstract]
"The spinocerebellar ataxia-associated gene tau tubulin kinase 2 controls the initiation of ciliogenesis."
Cell 151:847-858(2012) [PubMed] [Europe PMC] [Abstract]
"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
"Missense exchanges in the TTBK2 gene mutated in SCA11."
J. Neurol. 256:1856-1859(2009) [PubMed] [Europe PMC] [Abstract]