Tubulin Folding Cofactor B (TBCB)

TBC-B; CG22; CKAP1; CKAPI; Cytoskeleton-Associated Protein 1; Cytoskeleton-associated protein CKAPI; Tubulin-specific chaperone B

SPN	S077
HGNC	1989
MGI	1913661
PubMed	17184771
RGD	1309965
UniProt	Q99426
Wiki	TBCB

The cytoskeleton is composed of 3 structural elements: actin filaments, microtubules, and intermediate filaments. Cytoskeletal activity is modulated by many cytoskeleton-associated proteins (CAPs). One group of CAPs is characterized by a highly conserved glycine motif, the CAP-GLY domain, which may contribute to its association with microtubules. Members of the group of CAPs include dynactin, the dynein-associated protein. Watanabe et al. (1996) isolated a novel member of this family, which they called CKAPI (for cytoskeleton-associated protein I, glycine motif). The cDNA was isolated from a human fetal-brain cDNA library and found to contain an open reading frame of 579 nucleotides encoding a 193-amino acid polypeptide. Three transcripts of different sizes were expressed in all tissues examined.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS077Hu01	Recombinant Tubulin Folding Cofactor B (TBCB)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS077Hu01	Monoclonal Antibody to Tubulin Folding Cofactor B (TBCB)	WB; IHC; ICC; IP.
Antibodies	PAS077Hu01	Polyclonal Antibody to Tubulin Folding Cofactor B (TBCB)	WB; IHC; ICC; IF.
Assay Kits	CLS077Hu01	CLIA Kit for Tubulin Folding Cofactor B (TBCB)	CLIA assay for Antigen Detection
Assay Kits	ELS077Hu01	ELISA Kit for Tubulin Folding Cofactor B (TBCB)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS077Mu01	Recombinant Tubulin Folding Cofactor B (TBCB)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS077Mu01	Monoclonal Antibody to Tubulin Folding Cofactor B (TBCB)	WB; IHC; ICC; IP.
Antibodies	PAS077Mu01	Polyclonal Antibody to Tubulin Folding Cofactor B (TBCB)	WB; IHC; ICC; IF.
Assay Kits	CLS077Mu01	CLIA Kit for Tubulin Folding Cofactor B (TBCB)	CLIA assay for Antigen Detection
Assay Kits	ELS077Mu01	ELISA Kit for Tubulin Folding Cofactor B (TBCB)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS077Ra01	Recombinant Tubulin Folding Cofactor B (TBCB)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS077Ra01	Monoclonal Antibody to Tubulin Folding Cofactor B (TBCB)	WB; IHC; ICC; IP.
Antibodies	PAS077Ra01	Polyclonal Antibody to Tubulin Folding Cofactor B (TBCB)	WB; IHC; ICC; IF.
Assay Kits	CLS077Ra01	CLIA Kit for Tubulin Folding Cofactor B (TBCB)	CLIA assay for Antigen Detection
Assay Kits	ELS077Ra01	ELISA Kit for Tubulin Folding Cofactor B (TBCB)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS077Ca01	Recombinant Tubulin Folding Cofactor B (TBCB)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS077Ca01	Monoclonal Antibody to Tubulin Folding Cofactor B (TBCB)	WB; IHC; ICC; IP.
Antibodies	PAS077Ca01	Polyclonal Antibody to Tubulin Folding Cofactor B (TBCB)	WB; IHC; ICC; IF.
Assay Kits	CLS077Ca01	CLIA Kit for Tubulin Folding Cofactor B (TBCB)	CLIA assay for Antigen Detection
Assay Kits	ELS077Ca01	ELISA Kit for Tubulin Folding Cofactor B (TBCB)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS077Po01	Recombinant Tubulin Folding Cofactor B (TBCB)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS077Po01	Monoclonal Antibody to Tubulin Folding Cofactor B (TBCB)	WB; IHC; ICC; IP.
Antibodies	PAS077Po01	Polyclonal Antibody to Tubulin Folding Cofactor B (TBCB)	WB; IHC; ICC; IF.
Assay Kits	CLS077Po01	CLIA Kit for Tubulin Folding Cofactor B (TBCB)	CLIA assay for Antigen Detection
Assay Kits	ELS077Po01	ELISA Kit for Tubulin Folding Cofactor B (TBCB)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS077Bo01	Recombinant Tubulin Folding Cofactor B (TBCB)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS077Bo01	Monoclonal Antibody to Tubulin Folding Cofactor B (TBCB)	WB; IHC; ICC; IP.
Antibodies	PAS077Bo01	Polyclonal Antibody to Tubulin Folding Cofactor B (TBCB)	WB; IHC; ICC; IF.
Assay Kits	CLS077Bo01	CLIA Kit for Tubulin Folding Cofactor B (TBCB)	CLIA assay for Antigen Detection
Assay Kits	ELS077Bo01	ELISA Kit for Tubulin Folding Cofactor B (TBCB)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS077Rb01	Recombinant Tubulin Folding Cofactor B (TBCB)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS077Rb01	Monoclonal Antibody to Tubulin Folding Cofactor B (TBCB)	WB; IHC; ICC; IP.
Antibodies	PAS077Rb01	Polyclonal Antibody to Tubulin Folding Cofactor B (TBCB)	WB; IHC; ICC; IF.
Assay Kits	CLS077Rb01	CLIA Kit for Tubulin Folding Cofactor B (TBCB)	CLIA assay for Antigen Detection
Assay Kits	ELS077Rb01	ELISA Kit for Tubulin Folding Cofactor B (TBCB)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS077Mo01	Recombinant Tubulin Folding Cofactor B (TBCB)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS077Mo01	Monoclonal Antibody to Tubulin Folding Cofactor B (TBCB)	WB; IHC; ICC; IP.
Antibodies	PAS077Mo01	Polyclonal Antibody to Tubulin Folding Cofactor B (TBCB)	WB; IHC; ICC; IF.
Assay Kits	CLS077Mo01	CLIA Kit for Tubulin Folding Cofactor B (TBCB)	CLIA assay for Antigen Detection
Assay Kits	ELS077Mo01	ELISA Kit for Tubulin Folding Cofactor B (TBCB)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors."
J. Cell Biol. 138:821-832(1997) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning, expression, and mapping of CKAPI, which encodes a putative cytoskeleton-associated protein containing a CAP-Gly domain."
Cytogenet. Cell Genet. 72:208-211(1996) [PubMed] [Europe PMC] [Abstract]

"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]

"Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway."
Curr. Biol. 15:2050-2055(2005) [PubMed] [Europe PMC] [Abstract]

"p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B."
Mol. Cell. Biol. 25:3726-3736(2005) [PubMed] [Europe PMC] [Abstract]

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]