Interleukin 22 Receptor Alpha 2 (IL22Ra2)

CRF2-S1; IL-22BP; ZcytoR16; Cytokine receptor class-II member 10; Cytokine receptor family type 2, soluble 1; Interleukin-22-binding protein

SPN	S046
HGNC	14901
MGI	2665114
PubMed	24284923
RGD	1303169
UniProt	Q969J5
Wiki	IL22RA2

IL22Ra2 is a soluble class II cytokine receptor. This protein has been shown to specifically bind to interleukin 22 (IL22), block the interaction of IL22 with its cell surface receptor, and thus inhibit IL22 activity. This protein functions as an IL22 antagonist, and may be important in the regulation of inflammatory response. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach.

Reference

"A novel, soluble homologue of the human IL-10 receptor with preferential expression in placenta."
Genes Immun. 2:329-334(2001) [PubMed] [Europe PMC] [Abstract]

"Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity."
J. Immunol. 166:7096-7103(2001) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22."
J. Immunol. 166:7090-7095(2001) [PubMed] [Europe PMC] [Abstract]

"A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist."
Proc. Natl. Acad. Sci. U.S.A. 98:9511-9516(2001) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart."
Genes Immun. 5:330-336(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of mouse IL-22 binding protein."
Genes Immun. 4:204-211(2003) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22."
FEBS Lett. 583:1072-1077(2009) [PubMed] [Europe PMC] [Abstract]