Alcohol Dehydrogenase 7 (ADH7)

Alcohol dehydrogenase class 4 mu/sigma chain; Alcohol dehydrogenase class IV mu/sigma chain; Gastric alcohol dehydrogenase

SPN	R947
HGNC	256
MGI	87926
PubMed	22144473
RGD	621638
UniProt	P40394
Wiki	ADH7

ADH7 encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products.

The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants.

Reference

"Alcohol dehydrogenase of class IV (sigma sigma-ADH) from human stomach. cDNA sequence and structure/function relationships."
Eur. J. Biochem. 224:549-557(1994) [PubMed] [Europe PMC] [Abstract]

"The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase) determined from the ADH7 gene."
J. Biol. Chem. 269:15606-15612(1994) [PubMed] [Europe PMC] [Abstract]

"Genomic structure and expression of the ADH7 gene encoding human class IV alcohol dehydrogenase, the form most efficient for retinol metabolism in vitro."
J. Biol. Chem. 270:4305-4311(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Molecular characterization of a class IV human alcohol dehydrogenase gene (ADH7)."
FEBS Lett. 351:411-415(1994) [PubMed] [Europe PMC] [Abstract]

"Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase. Active-site amino acid sequence explains substrate specificity compared with liver isozymes."
J. Biol. Chem. 270:3625-3630(1995) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and chromosomal localization of the ADH7 gene encoding human class IV (sigma) ADH."
Genomics 31:243-245(1996) [PubMed] [Europe PMC] [Abstract]

"Class IV alcohol dehydrogenase (the gastric enzyme). Structural analysis of human sigma sigma-ADH reveals class IV to be variable and confirms the presence of a fifth mammalian alcohol dehydrogenase class."
FEBS Lett. 303:69-72(1992) [PubMed] [Europe PMC] [Abstract]

"Human stomach class IV alcohol dehydrogenase: molecular genetic analysis."
Alcohol. Clin. Exp. Res. 19:185-186(1995) [PubMed] [Europe PMC] [Abstract]

"X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity."
J. Biol. Chem. 272:18558-18563(1997) [PubMed] [Europe PMC] [Abstract]

"Methionine-141 directly influences the binding of 4-methylpyrazole in human sigma sigma alcohol dehydrogenase."
Protein Sci. 8:2639-2644(1999) [PubMed] [Europe PMC] [Abstract]