Sorting Nexin 9 (SNX9)

SDP1; SH3PX1; SH3PXD3A; WISP; SH3 and PX domain-containing protein 1; SH3 and PX domain-containing protein 3A

SPN	R923
HGNC	14973
MGI	1913866
PubMed	18388313
UniProt	Q9Y5X1
Wiki	SNX9

Sorting nexin-9 is a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain an SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein.

Reference

"A large family of endosome-localized proteins related to sorting nexin 1."
Biochem. J. 358:7-16(2001) [PubMed] [Europe PMC] [Abstract]

"Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1."
J. Biol. Chem. 274:31693-31699(1999) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation."
J. Biol. Chem. 277:10134-10138(2002) [PubMed] [Europe PMC] [Abstract]

"Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components."
J. Biol. Chem. 278:46772-46781(2003) [PubMed] [Europe PMC] [Abstract]

"SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1."
FEBS Lett. 579:5040-5048(2005) [PubMed] [Europe PMC] [Abstract]

"SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis."
Mol. Biol. Cell 16:2058-2067(2005) [PubMed] [Europe PMC] [Abstract]

"Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2."
Biochem. J. 394:693-698(2006) [PubMed] [Europe PMC] [Abstract]

"SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis."
Dev. Cell 13:43-56(2007) [PubMed] [Europe PMC] [Abstract]

"SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2."
J. Cell Sci. 121:1252-1263(2008) [PubMed] [Europe PMC] [Abstract]

"Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain."
FEBS J. 277:2803-2814(2010) [PubMed] [Europe PMC] [Abstract]

"SNX18 shares a redundant role with SNX9 and modulates endocytic trafficking at the plasma membrane."
J. Cell Sci. 123:1742-1750(2010) [PubMed] [Europe PMC] [Abstract]

"The SNX-PX-BAR family in macropinocytosis: the regulation of macropinosome formation by SNX-PX-BAR proteins."
PLoS ONE 5:E13763-E13763(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis."
J. Cell Sci. 125:4372-4382(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"The PX-BAR membrane-remodeling unit of sorting nexin 9."
EMBO J. 26:4788-4800(2007) [PubMed] [Europe PMC] [Abstract]

"Structure and plasticity of Endophilin and Sorting Nexin 9."
Structure 16:1574-1587(2008) [PubMed] [Europe PMC] [Abstract]

"Mechanism of aldolase control of sorting nexin 9 function in endocytosis."
J. Biol. Chem. 285:11983-11990(2010) [PubMed] [Europe PMC] [Abstract]