Histone Deacetylase 9 (HDAC9)

HD7; HDAC; HDAC7; HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR; Histone deacetylase-related protein; MEF2-interacting transcription repressor MITR; Histone deacetylase 7B

SPN	R890
HGNC	14065
MGI	1931221
PubMed	22306652
RGD	1310748
UniProt	Q9UKV0
Wiki	HDAC9

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family.

HDAC9 is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.

Reference

"Cloning and characterization of a histone deacetylase, HDAC9."
Proc. Natl. Acad. Sci. U.S.A. 98:10572-10577(2001) [PubMed] [Europe PMC] [Abstract]

"Molecular characterization of a familial translocation implicates disruption of HDAC9 and possible position effect on TGFbeta2 in the pathogenesis of Peters' anomaly."
Genomics 81:489-503(2003) [PubMed] [Europe PMC] [Abstract]

"The histone deacetylase 9 gene encodes multiple protein isoforms."
J. Biol. Chem. 278:16059-16072(2003) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor."
Mol. Cell. Biol. 19:7816-7827(1999) [PubMed] [Europe PMC] [Abstract]

"MEF-2 function is modified by a novel co-repressor, MITR."
EMBO J. 18:5085-5098(1999) [PubMed] [Europe PMC] [Abstract]

"Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5."
Proc. Natl. Acad. Sci. U.S.A. 97:1056-1061(2000) [PubMed] [Europe PMC] [Abstract]

"HDAC4 deacetylase associates with and represses the MEF2 transcription factor."
EMBO J. 18:5099-5107(1999) [PubMed] [Europe PMC] [Abstract]

"The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase."
EMBO J. 21:2682-2691(2002) [PubMed] [Europe PMC] [Abstract]

"Neuroprotection by histone deacetylase-related protein."
Mol. Cell. Biol. 26:3550-3564(2006) [PubMed] [Europe PMC] [Abstract]

"FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression."
Proc. Natl. Acad. Sci. U.S.A. 104:4571-4576(2007) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases."
FEBS Lett. 584:1103-1110(2010) [PubMed] [Europe PMC] [Abstract]

"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma."
Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]