Vav 3 Oncogene (VAV3)

Vav 3 Guanine Nucleotide Exchange Factor

SPN	R870
HGNC	12659
MGI	1888518
PubMed	22692505
RGD	1565941
UniProt	Q9UKW4
Wiki	VAV3

Guanine nucleotide exchange factor VAV3 is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations.

This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. VAV proteins are an essential and direct link between receptors with intrinsic or associated tyrosine kinase activity and the mitogenic and cytoskeletal pathways regulated by Rho/Rac proteins .

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR870Hu01	Recombinant Vav 3 Oncogene (VAV3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR870Hu01	Monoclonal Antibody to Vav 3 Oncogene (VAV3)	WB; IHC; ICC; IP.
Antibodies	PAR870Hu01	Polyclonal Antibody to Vav 3 Oncogene (VAV3)	WB; IHC; ICC; IF.
Assay Kits	CLR870Hu01	CLIA Kit for Vav 3 Oncogene (VAV3)	CLIA assay for Antigen Detection
Assay Kits	ELR870Hu01	ELISA Kit for Vav 3 Oncogene (VAV3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR870Mu01	Recombinant Vav 3 Oncogene (VAV3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR870Mu01	Monoclonal Antibody to Vav 3 Oncogene (VAV3)	WB; IHC; ICC; IP.
Antibodies	PAR870Mu01	Polyclonal Antibody to Vav 3 Oncogene (VAV3)	WB; IHC; ICC; IF.
Assay Kits	CLR870Mu01	CLIA Kit for Vav 3 Oncogene (VAV3)	CLIA assay for Antigen Detection
Assay Kits	ELR870Mu01	ELISA Kit for Vav 3 Oncogene (VAV3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR870Ra01	Recombinant Vav 3 Oncogene (VAV3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR870Ra01	Monoclonal Antibody to Vav 3 Oncogene (VAV3)	WB; IHC; ICC; IP.
Antibodies	PAR870Ra01	Polyclonal Antibody to Vav 3 Oncogene (VAV3)	WB; IHC; ICC; IF.
Assay Kits	CLR870Ra01	CLIA Kit for Vav 3 Oncogene (VAV3)	CLIA assay for Antigen Detection
Assay Kits	ELR870Ra01	ELISA Kit for Vav 3 Oncogene (VAV3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR870Ca01	Recombinant Vav 3 Oncogene (VAV3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR870Ca01	Monoclonal Antibody to Vav 3 Oncogene (VAV3)	WB; IHC; ICC; IP.
Antibodies	PAR870Ca01	Polyclonal Antibody to Vav 3 Oncogene (VAV3)	WB; IHC; ICC; IF.
Assay Kits	CLR870Ca01	CLIA Kit for Vav 3 Oncogene (VAV3)	CLIA assay for Antigen Detection
Assay Kits	ELR870Ca01	ELISA Kit for Vav 3 Oncogene (VAV3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR870Po01	Recombinant Vav 3 Oncogene (VAV3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR870Po01	Monoclonal Antibody to Vav 3 Oncogene (VAV3)	WB; IHC; ICC; IP.
Antibodies	PAR870Po01	Polyclonal Antibody to Vav 3 Oncogene (VAV3)	WB; IHC; ICC; IF.
Assay Kits	CLR870Po01	CLIA Kit for Vav 3 Oncogene (VAV3)	CLIA assay for Antigen Detection
Assay Kits	ELR870Po01	ELISA Kit for Vav 3 Oncogene (VAV3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR870Bo01	Recombinant Vav 3 Oncogene (VAV3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR870Bo01	Monoclonal Antibody to Vav 3 Oncogene (VAV3)	WB; IHC; ICC; IP.
Antibodies	PAR870Bo01	Polyclonal Antibody to Vav 3 Oncogene (VAV3)	WB; IHC; ICC; IF.
Assay Kits	CLR870Bo01	CLIA Kit for Vav 3 Oncogene (VAV3)	CLIA assay for Antigen Detection
Assay Kits	ELR870Bo01	ELISA Kit for Vav 3 Oncogene (VAV3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR870Rb01	Recombinant Vav 3 Oncogene (VAV3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR870Rb01	Monoclonal Antibody to Vav 3 Oncogene (VAV3)	WB; IHC; ICC; IP.
Antibodies	PAR870Rb01	Polyclonal Antibody to Vav 3 Oncogene (VAV3)	WB; IHC; ICC; IF.
Assay Kits	CLR870Rb01	CLIA Kit for Vav 3 Oncogene (VAV3)	CLIA assay for Antigen Detection
Assay Kits	ELR870Rb01	ELISA Kit for Vav 3 Oncogene (VAV3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR870Mo01	Recombinant Vav 3 Oncogene (VAV3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR870Mo01	Monoclonal Antibody to Vav 3 Oncogene (VAV3)	WB; IHC; ICC; IP.
Antibodies	PAR870Mo01	Polyclonal Antibody to Vav 3 Oncogene (VAV3)	WB; IHC; ICC; IF.
Assay Kits	CLR870Mo01	CLIA Kit for Vav 3 Oncogene (VAV3)	CLIA assay for Antigen Detection
Assay Kits	ELR870Mo01	ELISA Kit for Vav 3 Oncogene (VAV3)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Non-stoichiometric reduced complexity probes for cDNA arrays."
Nucleic Acids Res. 26:3883-3891(1998) [PubMed] [Europe PMC] [Abstract]

"Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins."
Mol. Cell. Biol. 19:7870-7885(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation."
Mol. Cell. Biol. 20:9212-9224(2000) [PubMed] [Europe PMC] [Abstract]

"Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity."
Oncogene 21:7720-7729(2002) [PubMed] [Europe PMC] [Abstract]

"Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis."
Mol. Cell. Biol. 26:4830-4842(2006) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the CH domain from human VAV-3 protein."
Submitted (DEC-2006) to the PDB data bank