Eukaryotic Translation Initiation Factor 2C1 (EIF2C1)

AGO1; EIF2C; GERP95; Q99; Protein Argonaute-1; Argonaute RISC catalytic component 1; Putative RNA-binding protein Q99

SPN	R812
HGNC	3262
MGI	2446630
PubMed	15152257
RGD	1304619
UniProt	Q9UL18
Wiki	EIF2C1

EIF2C1 encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and argonaute 4.To obtain genomic sequence information, they isolated a P1 genomic clone containing the EIF2C1 locus. The human EIF2C1 gene encodes a protein of 857 amino acids. The 2,571-bp open reading frame is flanked by 238 bp of 5-prime sequence and an extremely large 3-prime untranslated region with multiple short repeated segments composed of mono-, tri-, or quatronucleotides interspersed throughout.

Reference

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Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

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Mol. Cell 15:185-197(2004) [PubMed] [Europe PMC] [Abstract]

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"Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54."
PLoS Biol. 4:E210-E210(2006) [PubMed] [Europe PMC] [Abstract]

"Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells."
EMBO Rep. 8:1052-1060(2007) [PubMed] [Europe PMC] [Abstract]

"Importance of translation and nonnucleolytic ago proteins for on-target RNA interference."
Curr. Biol. 18:1327-1332(2008) [PubMed] [Europe PMC] [Abstract]

"Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs."
Cell 136:496-507(2009) [PubMed] [Europe PMC] [Abstract]

"LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing."
Proc. Natl. Acad. Sci. U.S.A. 107:12499-12504(2010) [PubMed] [Europe PMC] [Abstract]

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Nature 429:318-322(2004) [PubMed] [Europe PMC] [Abstract]

"Eukaryote-specific insertion elements control human ARGONAUTE slicer activity."
Cell Rep. 3:1893-1900(2013) [PubMed] [Europe PMC] [Abstract]

"The making of a slicer: activation of human Argonaute-1."
Cell Rep. 3:1901-1909(2013) [PubMed] [Europe PMC] [Abstract]