Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1)

EIF-2; EIF-2A; EIF-2alpha; EIF2; EIF2A; Eukaryotic translation initiation factor 2 subunit alpha

SPN	R809
HGNC	3265
MGI	95299
PubMed	2948954
RGD	620963
UniProt	P05198
Wiki	EIF2S1

EIF2S1 encoded by this gene is the alpha subunit of the translation initiation factor eIF2 complex which catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (36 kD, this article), beta (38 kD), and gamma (52 kD). The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2-alpha. Salubrinal is a selective inhibitor of enzymes that dephosphorylate EIF2-alpha. Salubrinal also blocks EIF2-alpha dephosphorylation by a herpes simplex virus protein and inhibits viral replication. EIF2-alpha phosphorylation is cytoprotective during endoplasmic reticulum stress.

Reference

"Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA."
J. Biol. Chem. 262:1206-1212(1987) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L."
Virology 324:419-429(2004) [PubMed] [Europe PMC] [Abstract]

"The N-terminal region of ABC50 interacts with eukaryotic initiation factor eIF2 and is a target for regulatory phosphorylation by CK2."
Biochem. J. 409:223-231(2008) [PubMed] [Europe PMC] [Abstract]

"Rotavirus infection induces the phosphorylation of eIF2alpha but prevents the formation of stress granules."
J. Virol. 82:1496-1504(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha."
J. Biol. Chem. 277:17057-17061(2002) [PubMed] [Europe PMC] [Abstract]

"Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B."
Structure 12:1693-1704(2004) [PubMed] [Europe PMC] [Abstract]