Mediator Complex Subunit 6 (MED6)

NY-REN-28; ARC33; Activator-recruited cofactor 33 kDa component; Renal carcinoma antigen NY-REN-28; Mediator of RNA polymerase II transcription subunit 6

SPN	R706
HGNC	19970
MGI	1917042
PubMed	9234719
RGD	1310296
UniProt	O75586
Wiki	MED6

One type of intermediary is the mediator complex, which consists of approximately 20 polypeptides. It is physically associated with RNA polymerase II and is essential for transcriptional activation. Lee et al. (1997) found that the S. cerevisiae Med6 protein, a component of the mediator complex, was absolutely required for transcriptional activation of most of the RNA polymerase II-transcribed genes tested; it had no effect on uninduced or repressed transcription, transcription of constitutively expressed genes, or transcription by RNA polymerases I or III. By searching sequence databases with the yeast Med6 protein, Lee et al. (1997) identified an expressed sequence tag containing the complete human MED6 coding sequence. The predicted 157-amino acid human MED6 protein is 30% similar to yeast Med6.

Reference

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Mol. Cell 3:97-108(1999) [PubMed] [Europe PMC] [Abstract]

Erratum
Mol. Cell 3:541-541(1999)

"TFIIH is negatively regulated by cdk8-containing mediator complexes."
Nature 407:102-106(2000) [PubMed] [Europe PMC] [Abstract]

"The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro."
Proc. Natl. Acad. Sci. U.S.A. 99:2642-2647(2002) [PubMed] [Europe PMC] [Abstract]

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Mol. Cell 14:685-691(2004) [PubMed] [Europe PMC] [Abstract]

"MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."
Mol. Cell 19:89-100(2005) [PubMed] [Europe PMC] [Abstract]

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J. Biol. Chem. 281:14691-14699(2006) [PubMed] [Europe PMC] [Abstract]

"Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly."
J. Biol. Chem. 281:15172-15181(2006) [PubMed] [Europe PMC] [Abstract]

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Mol. Cell. Biol. 26:8667-8682(2006) [PubMed] [Europe PMC] [Abstract]

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