Serine/Arginine Rich Splicing Factor 2 (SRSF2)
SFRS2; PR264; SC-35; SC35; SFRS2A; SRp30b; Splicing component, 35 kDa; Splicing factor, arginine/serine-rich 2
SFRS2 contains a ribonucleoprotein (RNP)-type RNA-binding motif and a carboxyl-terminal serine/arginine-rich (SR) domain.in every member of the human SR family of splicing regulators, highly or ultraconserved elements are alternatively spliced, either as alternative 'poison cassette exons' containing early in-frame stop codons, or as alternative introns in the 3-prime untranslated region. These alternative splicing events target the resulting mRNAs for degradation by means of an RNA surveillance pathway called nonsense-mediated mRNA decay. Mouse orthologs of the human SR proteins exhibit the same unproductive splicing patterns. Three SR proteins, SRp20, SC35, and 9G8 (SFRS7), had been previously shown to direct splicing of their own transcripts, and SC35 autoregulates its expression by coupling alternative splicing with decay.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR700Hu01 | Recombinant Serine/Arginine Rich Splicing Factor 2 (SRSF2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR700Hu01 | Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 2 (SRSF2) | WB; IHC; ICC; IP. |
| PAR700Hu01 | Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 2 (SRSF2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR700Hu01 | CLIA Kit for Serine/Arginine Rich Splicing Factor 2 (SRSF2) | CLIA assay for Antigen Detection |
| ELR700Hu01 | ELISA Kit for Serine/Arginine Rich Splicing Factor 2 (SRSF2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR700Mu01 | Recombinant Serine/Arginine Rich Splicing Factor 2 (SRSF2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR700Mu01 | Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 2 (SRSF2) | WB; IHC; ICC; IP. |
| PAR700Mu01 | Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 2 (SRSF2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR700Mu01 | CLIA Kit for Serine/Arginine Rich Splicing Factor 2 (SRSF2) | CLIA assay for Antigen Detection |
| ELR700Mu01 | ELISA Kit for Serine/Arginine Rich Splicing Factor 2 (SRSF2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR700Ra01 | Recombinant Serine/Arginine Rich Splicing Factor 2 (SRSF2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR700Ra01 | Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 2 (SRSF2) | WB; IHC; ICC; IP. |
| PAR700Ra01 | Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 2 (SRSF2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR700Ra01 | CLIA Kit for Serine/Arginine Rich Splicing Factor 2 (SRSF2) | CLIA assay for Antigen Detection |
| ELR700Ra01 | ELISA Kit for Serine/Arginine Rich Splicing Factor 2 (SRSF2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR700Ca01 | Recombinant Serine/Arginine Rich Splicing Factor 2 (SRSF2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR700Ca01 | Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 2 (SRSF2) | WB; IHC; ICC; IP. |
| PAR700Ca01 | Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 2 (SRSF2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR700Ca01 | CLIA Kit for Serine/Arginine Rich Splicing Factor 2 (SRSF2) | CLIA assay for Antigen Detection |
| ELR700Ca01 | ELISA Kit for Serine/Arginine Rich Splicing Factor 2 (SRSF2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR700Po01 | Recombinant Serine/Arginine Rich Splicing Factor 2 (SRSF2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR700Po01 | Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 2 (SRSF2) | WB; IHC; ICC; IP. |
| PAR700Po01 | Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 2 (SRSF2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR700Po01 | CLIA Kit for Serine/Arginine Rich Splicing Factor 2 (SRSF2) | CLIA assay for Antigen Detection |
| ELR700Po01 | ELISA Kit for Serine/Arginine Rich Splicing Factor 2 (SRSF2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR700Bo01 | Recombinant Serine/Arginine Rich Splicing Factor 2 (SRSF2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR700Bo01 | Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 2 (SRSF2) | WB; IHC; ICC; IP. |
| PAR700Bo01 | Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 2 (SRSF2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR700Bo01 | CLIA Kit for Serine/Arginine Rich Splicing Factor 2 (SRSF2) | CLIA assay for Antigen Detection |
| ELR700Bo01 | ELISA Kit for Serine/Arginine Rich Splicing Factor 2 (SRSF2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR700Rb01 | Recombinant Serine/Arginine Rich Splicing Factor 2 (SRSF2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR700Rb01 | Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 2 (SRSF2) | WB; IHC; ICC; IP. |
| PAR700Rb01 | Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 2 (SRSF2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR700Rb01 | CLIA Kit for Serine/Arginine Rich Splicing Factor 2 (SRSF2) | CLIA assay for Antigen Detection |
| ELR700Rb01 | ELISA Kit for Serine/Arginine Rich Splicing Factor 2 (SRSF2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR700Mo01 | Recombinant Serine/Arginine Rich Splicing Factor 2 (SRSF2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR700Mo01 | Monoclonal Antibody to Serine/Arginine Rich Splicing Factor 2 (SRSF2) | WB; IHC; ICC; IP. |
| PAR700Mo01 | Polyclonal Antibody to Serine/Arginine Rich Splicing Factor 2 (SRSF2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR700Mo01 | CLIA Kit for Serine/Arginine Rich Splicing Factor 2 (SRSF2) | CLIA assay for Antigen Detection |
| ELR700Mo01 | ELISA Kit for Serine/Arginine Rich Splicing Factor 2 (SRSF2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Isolation of a complementary DNA that encodes the mammalian splicing factor SC35."
Science 256:535-538(1992) [PubMed] [Europe PMC] [Abstract]
"A potential splicing factor is encoded by the opposite strand of the trans-spliced c-myb exon."
Proc. Natl. Acad. Sci. U.S.A. 89:2511-2515(1992) [PubMed] [Europe PMC] [Abstract]
"Several mRNAs with variable 3' untranslated regions and different stability encode the human PR264/SC35 splicing factor."
Proc. Natl. Acad. Sci. U.S.A. 91:932-936(1994) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The PR264/c-myb connection: expression of a splicing factor modulated by a nuclear protooncogene."
Proc. Natl. Acad. Sci. U.S.A. 89:11683-11687(1992) [PubMed] [Europe PMC] [Abstract]