Ubiquitin Specific Peptidase 14 (USP14)

TGT; tRNA-Guanine Transglycosylase; Ubiquitin Specific Protease 14; Deubiquitinating enzyme 14; Ubiquitin carboxyl-terminal hydrolase 14

SPN	R668
HGNC	12612
MGI	1928898
PubMed	24319254
RGD	1311825
UniProt	P54578
Wiki	USP14

Ubiquitin carboxyl-terminal hydrolase 14 is a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains.

This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Reference

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"USP14 inhibits ER-associated degradation via interaction with IRE1alpha."
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"Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK activation."
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"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14."
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