Exportin 5 (XPO5)
RANBP21; Exp5; Ran-binding protein 21
Exportin-5 belongs to a large family of karyopherins that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments. The deduced 1,205-amino acid protein has a calculated molecular mass of about 136 kD. XPO5 and XPO1 share 25% amino acid identity.
Northern blot analysis detected transcripts of about 3.6 and 5.0 kb in all tissues examined.XPO5 bound the nucleoporins NUP214 and NUP153 in a RAN-GTP-independent manner and bound a cargo protein, ILF3, in a RAN-GTP-dependent manner. XPO5 bound ILF3 at its double-stranded RNA-binding domain (dsRBD) and also bound the dsRBDs of other proteins. XPO5 directly interacted with VA1 RNA in a RAN-GTP-dependent manner.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR643Hu01 | Recombinant Exportin 5 (XPO5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR643Hu01 | Monoclonal Antibody to Exportin 5 (XPO5) | WB; IHC; ICC; IP. |
| PAR643Hu01 | Polyclonal Antibody to Exportin 5 (XPO5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR643Hu01 | CLIA Kit for Exportin 5 (XPO5) | CLIA assay for Antigen Detection |
| ELR643Hu01 | ELISA Kit for Exportin 5 (XPO5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR643Mu01 | Recombinant Exportin 5 (XPO5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR643Mu01 | Monoclonal Antibody to Exportin 5 (XPO5) | WB; IHC; ICC; IP. |
| PAR643Mu01 | Polyclonal Antibody to Exportin 5 (XPO5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR643Mu01 | CLIA Kit for Exportin 5 (XPO5) | CLIA assay for Antigen Detection |
| ELR643Mu01 | ELISA Kit for Exportin 5 (XPO5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR643Ra01 | Recombinant Exportin 5 (XPO5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR643Ra01 | Monoclonal Antibody to Exportin 5 (XPO5) | WB; IHC; ICC; IP. |
| PAR643Ra01 | Polyclonal Antibody to Exportin 5 (XPO5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR643Ra01 | CLIA Kit for Exportin 5 (XPO5) | CLIA assay for Antigen Detection |
| ELR643Ra01 | ELISA Kit for Exportin 5 (XPO5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR643Ca01 | Recombinant Exportin 5 (XPO5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR643Ca01 | Monoclonal Antibody to Exportin 5 (XPO5) | WB; IHC; ICC; IP. |
| PAR643Ca01 | Polyclonal Antibody to Exportin 5 (XPO5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR643Ca01 | CLIA Kit for Exportin 5 (XPO5) | CLIA assay for Antigen Detection |
| ELR643Ca01 | ELISA Kit for Exportin 5 (XPO5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR643Po01 | Recombinant Exportin 5 (XPO5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR643Po01 | Monoclonal Antibody to Exportin 5 (XPO5) | WB; IHC; ICC; IP. |
| PAR643Po01 | Polyclonal Antibody to Exportin 5 (XPO5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR643Po01 | CLIA Kit for Exportin 5 (XPO5) | CLIA assay for Antigen Detection |
| ELR643Po01 | ELISA Kit for Exportin 5 (XPO5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR643Bo01 | Recombinant Exportin 5 (XPO5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR643Bo01 | Monoclonal Antibody to Exportin 5 (XPO5) | WB; IHC; ICC; IP. |
| PAR643Bo01 | Polyclonal Antibody to Exportin 5 (XPO5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR643Bo01 | CLIA Kit for Exportin 5 (XPO5) | CLIA assay for Antigen Detection |
| ELR643Bo01 | ELISA Kit for Exportin 5 (XPO5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR643Rb01 | Recombinant Exportin 5 (XPO5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR643Rb01 | Monoclonal Antibody to Exportin 5 (XPO5) | WB; IHC; ICC; IP. |
| PAR643Rb01 | Polyclonal Antibody to Exportin 5 (XPO5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR643Rb01 | CLIA Kit for Exportin 5 (XPO5) | CLIA assay for Antigen Detection |
| ELR643Rb01 | ELISA Kit for Exportin 5 (XPO5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR643Mo01 | Recombinant Exportin 5 (XPO5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR643Mo01 | Monoclonal Antibody to Exportin 5 (XPO5) | WB; IHC; ICC; IP. |
| PAR643Mo01 | Polyclonal Antibody to Exportin 5 (XPO5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR643Mo01 | CLIA Kit for Exportin 5 (XPO5) | CLIA assay for Antigen Detection |
| ELR643Mo01 | ELISA Kit for Exportin 5 (XPO5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm."
EMBO J. 21:6205-6215(2002) [PubMed] [Europe PMC] [Abstract]
"Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins."
J. Cell Biol. 156:53-64(2002) [PubMed] [Europe PMC] [Abstract]
"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]