Death Associated Protein Kinase 3 (DAPK3)

ZIP; ZIPK; Dlk; DAP-like kinase; MYPT1 kinase; Zipper-interacting protein kinase

SPN	R640
HGNC	2676
MGI	1203520
PubMed	22868392
RGD	621766
UniProt	O43293
Wiki	DAPK3

Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.Saito et al. (1998) systematically screened serine/threonine protein kinases by reverse transcription-PCR with degenerated primers corresponding to the conserved regions of the protein kinase domain. One of the kinase genes identified showed a striking sequence homology to ZIP kinase reported by Kawai et al. (1998). Kawai et al. (1998) reported that the ZIP kinase induced morphologic changes in apoptosis in mammalian cells when overexpressed, suggesting that it plays an important role in the induction of apoptosis. The mRNA was ubiquitously expressed in various tissues.

Reference

"ZIP kinase, a novel serine/threonine kinase which mediates apoptosis."
Mol. Cell. Biol. 18:1642-1651(1998) [PubMed] [Europe PMC] [Abstract]

"ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells."
FEBS Lett. 451:81-84(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Novel ZIP kinase isoform lacks leucine zipper."
Arch. Biochem. Biophys. 456:194-203(2006) [PubMed] [Europe PMC] [Abstract]

"Zipper-interacting protein kinase induces Ca(2+)-free smooth muscle contraction via myosin light chain phosphorylation."
J. Biol. Chem. 276:29567-29574(2001) [PubMed] [Europe PMC] [Abstract]

"HeLa ZIP kinase induces diphosphorylation of myosin II regulatory light chain and reorganization of actin filaments in nonmuscle cells."
Oncogene 20:8175-8183(2001) [PubMed] [Europe PMC] [Abstract]

"ZIP kinase triggers apoptosis from nuclear PML oncogenic domains."
Mol. Cell. Biol. 23:6174-6186(2003) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase."
J. Biol. Chem. 279:42055-42061(2004) [PubMed] [Europe PMC] [Abstract]

"ZIP kinase is responsible for the phosphorylation of myosin II and necessary for cell motility in mammalian fibroblasts."
J. Cell Biol. 165:243-254(2004) [PubMed] [Europe PMC] [Abstract]

"Death-associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions."
Mol. Cell. Biol. 24:8611-8626(2004) [PubMed] [Europe PMC] [Abstract]

"Physical and functional interactions between STAT3 and ZIP kinase."
Int. Immunol. 17:1543-1552(2005) [PubMed] [Europe PMC] [Abstract]

"TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3."
Int. J. Androl. 28:163-170(2005) [PubMed] [Europe PMC] [Abstract]

"Regulation of zipper-interacting protein kinase activity in vitro and in vivo by multisite phosphorylation."
J. Biol. Chem. 280:9363-9374(2005) [PubMed] [Europe PMC] [Abstract]

"The death-associated protein kinases: structure, function, and beyond."
Annu. Rev. Biochem. 75:189-210(2006) [PubMed] [Europe PMC] [Abstract]

"ROCK1 phosphorylates and activates zipper-interacting protein kinase."
J. Biol. Chem. 282:4884-4893(2007) [PubMed] [Europe PMC] [Abstract]

"ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene."
PLoS Genet. 3:1884-1893(2007) [PubMed] [Europe PMC] [Abstract]

"Dlk/ZIP kinase, a novel Ser/Thr-specific protein kinase with multiple functions."
Signal Transduct. 7:248-259(2007)

"DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression."
Mol. Cell 32:371-382(2008) [PubMed] [Europe PMC] [Abstract]

"ZIP kinase plays a crucial role in androgen receptor-mediated transcription."
Oncogene 27:3292-3300(2008) [PubMed] [Europe PMC] [Abstract]

"Cancer-associated loss-of-function mutations implicate DAPK3 as a tumor-suppressing kinase."
Cancer Res. 71:3152-3161(2011) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation-dependent control of ZIPK nuclear import is species specific."
Cell. Signal. 23:297-303(2011) [PubMed] [Europe PMC] [Abstract]

"Atg1-mediated myosin II activation regulates autophagosome formation during starvation-induced autophagy."
EMBO J. 30:636-651(2011) [PubMed] [Europe PMC] [Abstract]

"Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4)."
J. Biol. Chem. 286:19170-19177(2011) [PubMed] [Europe PMC] [Abstract]

"New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform."
PLoS ONE 6:E17344-E17344(2011) [PubMed] [Europe PMC] [Abstract]

"Interaction of RhoD and ZIP kinase modulates actin filament assembly and focal adhesion dynamics."
Biochem. Biophys. Res. Commun. 433:163-169(2013) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human ZIP kinase."
Submitted (JUN-2006) to the PDB data bank

"Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites."
EMBO J. 27:704-714(2008) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]