Fucosyltransferase 8 (FUT8)

GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase; Alpha-(1,6)-fucosyltransferase

SPN	R604
HGNC	4019
MGI	1858901
PubMed	22011814
RGD	1303096
UniProt	Q9BYC5
Wiki	FUT8

FUT8 belongs to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternatively spliced variants encoding different isoforms have been identified.FUT8 is represented more frequently, possibly indicating that it has a higher level of expression than other FUT genes. They also identified a slightly longer alternatively spliced variant of FUT8 from retina cDNA libraries. The gene encodes a 575-amino acid polypeptide that has little sequence homology to other human fucosyltransferases.

Reference

"Purification and cDNA cloning of GDP-L-Fuc:N-acetyl-beta-D-glucosaminide:alpha1-6 fucosyltransferase (alpha1-6 FucT) from human gastric cancer MKN45 cells."
J. Biochem. 121:626-632(1997) [PubMed] [Europe PMC] [Abstract]

"Genomic structure and promoter analysis of the human alpha1,6-fucosyltransferase gene (FUT8)."
Glycobiology 10:637-643(2000) [PubMed] [Europe PMC] [Abstract]

"Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis."
Glycobiology 14:13-25(2004) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 14."
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A sequence motif involved in the donor substrate binding by alpha1,6-fucosyltransferase: the role of the conserved arginine residues."
Glycobiology 10:503-510(2000) [PubMed] [Europe PMC] [Abstract]

"A secreted tyrosine kinase acts in the extracellular environment."
Cell 158:1033-1044(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of mammalian alpha1,6-fucosyltransferase, FUT8."
Glycobiology 17:455-466(2007) [PubMed] [Europe PMC] [Abstract]