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Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D)

CACH3; CACN4; CACNL1A2; CCHL1A2; Cav1.3; Voltage-gated calcium channel subunit alpha Cav1.3; Calcium channel, L type, alpha-1 polypeptide, isoform 2

On the basis of their kinetics and pharmacology, 4 types of Ca(2+) currents have been described. The Ca(2+) channel activity associated with the skeletal muscle, heart, and neuroendocrine/brain alpha-1 subunit isoforms is inhibited by dihydropyridine (DHP) drugs, indicating that these represent L-type currents. By contrast, the activity of the brain isoform is not inhibited by dihydropyridine drugs and thus may represent a P-type current.
CACNA1D, the deduced 2,161-amino acid protein has a calculated molecular mass of 245 kD. The predicted structure consists of 4 repeating domains, each comprising 5 hydrophobic segments. There was evidence of alternative splicing.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR564Hu01 Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR564Hu01 Monoclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) WB; IHC; ICC; IP.
PAR564Hu01 Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) WB; IHC; ICC; IF.
Assay Kits CLR564Hu01 CLIA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) CLIA assay for Antigen Detection
ELR564Hu01 ELISA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR564Mu01 Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR564Mu01 Monoclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) WB; IHC; ICC; IP.
PAR564Mu01 Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) WB; IHC; ICC; IF.
Assay Kits CLR564Mu01 CLIA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) CLIA assay for Antigen Detection
ELR564Mu01 ELISA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR564Ra01 Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR564Ra01 Monoclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) WB; IHC; ICC; IP.
PAR564Ra01 Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) WB; IHC; ICC; IF.
Assay Kits CLR564Ra01 CLIA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) CLIA assay for Antigen Detection
ELR564Ra01 ELISA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR564Ca01 Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR564Ca01 Monoclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) WB; IHC; ICC; IP.
PAR564Ca01 Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) WB; IHC; ICC; IF.
Assay Kits CLR564Ca01 CLIA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) CLIA assay for Antigen Detection
ELR564Ca01 ELISA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR564Po01 Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR564Po01 Monoclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) WB; IHC; ICC; IP.
PAR564Po01 Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) WB; IHC; ICC; IF.
Assay Kits CLR564Po01 CLIA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) CLIA assay for Antigen Detection
ELR564Po01 ELISA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR564Bo01 Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR564Bo01 Monoclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) WB; IHC; ICC; IP.
PAR564Bo01 Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) WB; IHC; ICC; IF.
Assay Kits CLR564Bo01 CLIA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) CLIA assay for Antigen Detection
ELR564Bo01 ELISA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR564Rb01 Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR564Rb01 Monoclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) WB; IHC; ICC; IP.
PAR564Rb01 Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) WB; IHC; ICC; IF.
Assay Kits CLR564Rb01 CLIA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) CLIA assay for Antigen Detection
ELR564Rb01 ELISA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR564Mo01 Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR564Mo01 Monoclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) WB; IHC; ICC; IP.
PAR564Mo01 Polyclonal Antibody to Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) WB; IHC; ICC; IF.
Assay Kits CLR564Mo01 CLIA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) CLIA assay for Antigen Detection
ELR564Mo01 ELISA Kit for Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype."
Neuron 8:71-84(1992) [PubMed] [Europe PMC] [Abstract]

"Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells."
Proc. Natl. Acad. Sci. U.S.A. 89:584-588(1992) [PubMed] [Europe PMC] [Abstract]

"The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes."
Genomics 27:312-319(1995) [PubMed] [Europe PMC] [Abstract]

"Modulation of voltage- and Ca2+-dependent gating of CaV1.3 L-type calcium channels by alternative splicing of a C-terminal regulatory domain."
J. Biol. Chem. 283:20733-20744(2008) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"Genomic structure of the regulatory region of the voltage-gated calcium channel alpha 1D."
Exp. Mol. Med. 30:246-251(1998) [PubMed] [Europe PMC] [Abstract]

"Molecular diversity of neuronal-type calcium channels identified in small cell lung carcinoma."
Mayo Clin. Proc. 67:1150-1159(1992) [PubMed] [Europe PMC] [Abstract]

"Loss of recognition by cross-reactive T cells and its relation to a C-terminus-induced conformational reorientation of an HLA-B*2705-bound peptide."
Protein Sci. 20:278-290(2011) [PubMed] [Europe PMC] [Abstract]

"Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness."
Nat. Neurosci. 14:77-84(2011) [PubMed] [Europe PMC] [Abstract]

"Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism."
Nat. Genet. 45:1050-1054(2013) [PubMed] [Europe PMC] [Abstract]