Carbonyl Reductase 3 (CBR3)
SDR21C2; Short Chain Dehydrogenase/Reductase Family 21C,Member 2; NADPH-dependent carbonyl reductase 3
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. Carbonyl reductase (CBR) catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. By analyzing sequences from the 21q22.2 chromosomal region, Watanabe et al. (1998) identified genomic clones corresponding to CBR1 and to CBR3, a novel carbonyl reductase gene. The deduced 277-amino acid CBR3 protein is 84% similar to the CBR1 protein.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR537Hu01 | Recombinant Carbonyl Reductase 3 (CBR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR537Hu01 | Monoclonal Antibody to Carbonyl Reductase 3 (CBR3) | WB; IHC; ICC; IP. |
| PAR537Hu01 | Polyclonal Antibody to Carbonyl Reductase 3 (CBR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR537Hu01 | CLIA Kit for Carbonyl Reductase 3 (CBR3) | CLIA assay for Antigen Detection |
| ELR537Hu01 | ELISA Kit for Carbonyl Reductase 3 (CBR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR537Mu01 | Recombinant Carbonyl Reductase 3 (CBR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR537Mu01 | Monoclonal Antibody to Carbonyl Reductase 3 (CBR3) | WB; IHC; ICC; IP. |
| PAR537Mu01 | Polyclonal Antibody to Carbonyl Reductase 3 (CBR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR537Mu01 | CLIA Kit for Carbonyl Reductase 3 (CBR3) | CLIA assay for Antigen Detection |
| ELR537Mu01 | ELISA Kit for Carbonyl Reductase 3 (CBR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR537Ra01 | Recombinant Carbonyl Reductase 3 (CBR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR537Ra01 | Monoclonal Antibody to Carbonyl Reductase 3 (CBR3) | WB; IHC; ICC; IP. |
| PAR537Ra01 | Polyclonal Antibody to Carbonyl Reductase 3 (CBR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR537Ra01 | CLIA Kit for Carbonyl Reductase 3 (CBR3) | CLIA assay for Antigen Detection |
| ELR537Ra01 | ELISA Kit for Carbonyl Reductase 3 (CBR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR537Ca01 | Recombinant Carbonyl Reductase 3 (CBR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR537Ca01 | Monoclonal Antibody to Carbonyl Reductase 3 (CBR3) | WB; IHC; ICC; IP. |
| PAR537Ca01 | Polyclonal Antibody to Carbonyl Reductase 3 (CBR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR537Ca01 | CLIA Kit for Carbonyl Reductase 3 (CBR3) | CLIA assay for Antigen Detection |
| ELR537Ca01 | ELISA Kit for Carbonyl Reductase 3 (CBR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR537Po01 | Recombinant Carbonyl Reductase 3 (CBR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR537Po01 | Monoclonal Antibody to Carbonyl Reductase 3 (CBR3) | WB; IHC; ICC; IP. |
| PAR537Po01 | Polyclonal Antibody to Carbonyl Reductase 3 (CBR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR537Po01 | CLIA Kit for Carbonyl Reductase 3 (CBR3) | CLIA assay for Antigen Detection |
| ELR537Po01 | ELISA Kit for Carbonyl Reductase 3 (CBR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR537Bo01 | Recombinant Carbonyl Reductase 3 (CBR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR537Bo01 | Monoclonal Antibody to Carbonyl Reductase 3 (CBR3) | WB; IHC; ICC; IP. |
| PAR537Bo01 | Polyclonal Antibody to Carbonyl Reductase 3 (CBR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR537Bo01 | CLIA Kit for Carbonyl Reductase 3 (CBR3) | CLIA assay for Antigen Detection |
| ELR537Bo01 | ELISA Kit for Carbonyl Reductase 3 (CBR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR537Rb01 | Recombinant Carbonyl Reductase 3 (CBR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR537Rb01 | Monoclonal Antibody to Carbonyl Reductase 3 (CBR3) | WB; IHC; ICC; IP. |
| PAR537Rb01 | Polyclonal Antibody to Carbonyl Reductase 3 (CBR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR537Rb01 | CLIA Kit for Carbonyl Reductase 3 (CBR3) | CLIA assay for Antigen Detection |
| ELR537Rb01 | ELISA Kit for Carbonyl Reductase 3 (CBR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR537Mo01 | Recombinant Carbonyl Reductase 3 (CBR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR537Mo01 | Monoclonal Antibody to Carbonyl Reductase 3 (CBR3) | WB; IHC; ICC; IP. |
| PAR537Mo01 | Polyclonal Antibody to Carbonyl Reductase 3 (CBR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR537Mo01 | CLIA Kit for Carbonyl Reductase 3 (CBR3) | CLIA assay for Antigen Detection |
| ELR537Mo01 | ELISA Kit for Carbonyl Reductase 3 (CBR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2."
Genomics 52:95-100(1998) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 21."
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1."
Mol. Cell. Biochem. 315:113-121(2008) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of human carbonyl reductase 3, complexed with NADP+."
Submitted (FEB-2009) to the PDB data bank
"Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3)."
Drug Metab. Dispos. 33:254-257(2005) [PubMed] [Europe PMC] [Abstract]