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Claudin 2 (CLDN2)

SP82

Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions. The deduced protein contains 230 amino acids and shares 93% amino acid identity with mouse Cldn2. Immunostaining of mouse intestine detected higher Cldn2 expression in ileum than in jejunum. the intestine-specific homeodomain proteins CDX1 and CDX2 activated a reporter plasmid driven by the CLDN2 promoter. HNF1-alpha (TCF1) augmented the CDX2-induced activation, but not the CDX1-induced activation. In mice, Hnf1-alpha was required for Cldn2 expression in the villus epithelium of the ileum and within the liver, but not in the kidneys, indicating an organ-specific function of Hnf1-alpha in regulating Cldn2 gene expression.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR506Hu01 Recombinant Claudin 2 (CLDN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR506Hu01 Monoclonal Antibody to Claudin 2 (CLDN2) WB; IHC; ICC; IP.
PAR506Hu01 Polyclonal Antibody to Claudin 2 (CLDN2) WB; IHC; ICC; IF.
Assay Kits CLR506Hu01 CLIA Kit for Claudin 2 (CLDN2) CLIA assay for Antigen Detection
ELR506Hu01 ELISA Kit for Claudin 2 (CLDN2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR506Mu01 Recombinant Claudin 2 (CLDN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR506Mu01 Monoclonal Antibody to Claudin 2 (CLDN2) WB; IHC; ICC; IP.
PAR506Mu01 Polyclonal Antibody to Claudin 2 (CLDN2) WB; IHC; ICC; IF.
Assay Kits CLR506Mu01 CLIA Kit for Claudin 2 (CLDN2) CLIA assay for Antigen Detection
ELR506Mu01 ELISA Kit for Claudin 2 (CLDN2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR506Ra01 Recombinant Claudin 2 (CLDN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR506Ra01 Monoclonal Antibody to Claudin 2 (CLDN2) WB; IHC; ICC; IP.
PAR506Ra01 Polyclonal Antibody to Claudin 2 (CLDN2) WB; IHC; ICC; IF.
Assay Kits CLR506Ra01 CLIA Kit for Claudin 2 (CLDN2) CLIA assay for Antigen Detection
ELR506Ra01 ELISA Kit for Claudin 2 (CLDN2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR506Ca01 Recombinant Claudin 2 (CLDN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR506Ca01 Monoclonal Antibody to Claudin 2 (CLDN2) WB; IHC; ICC; IP.
PAR506Ca01 Polyclonal Antibody to Claudin 2 (CLDN2) WB; IHC; ICC; IF.
Assay Kits CLR506Ca01 CLIA Kit for Claudin 2 (CLDN2) CLIA assay for Antigen Detection
ELR506Ca01 ELISA Kit for Claudin 2 (CLDN2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR506Po01 Recombinant Claudin 2 (CLDN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR506Po01 Monoclonal Antibody to Claudin 2 (CLDN2) WB; IHC; ICC; IP.
PAR506Po01 Polyclonal Antibody to Claudin 2 (CLDN2) WB; IHC; ICC; IF.
Assay Kits CLR506Po01 CLIA Kit for Claudin 2 (CLDN2) CLIA assay for Antigen Detection
ELR506Po01 ELISA Kit for Claudin 2 (CLDN2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR506Bo01 Recombinant Claudin 2 (CLDN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR506Bo01 Monoclonal Antibody to Claudin 2 (CLDN2) WB; IHC; ICC; IP.
PAR506Bo01 Polyclonal Antibody to Claudin 2 (CLDN2) WB; IHC; ICC; IF.
Assay Kits CLR506Bo01 CLIA Kit for Claudin 2 (CLDN2) CLIA assay for Antigen Detection
ELR506Bo01 ELISA Kit for Claudin 2 (CLDN2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR506Rb01 Recombinant Claudin 2 (CLDN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR506Rb01 Monoclonal Antibody to Claudin 2 (CLDN2) WB; IHC; ICC; IP.
PAR506Rb01 Polyclonal Antibody to Claudin 2 (CLDN2) WB; IHC; ICC; IF.
Assay Kits CLR506Rb01 CLIA Kit for Claudin 2 (CLDN2) CLIA assay for Antigen Detection
ELR506Rb01 ELISA Kit for Claudin 2 (CLDN2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR506Mo01 Recombinant Claudin 2 (CLDN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR506Mo01 Monoclonal Antibody to Claudin 2 (CLDN2) WB; IHC; ICC; IP.
PAR506Mo01 Polyclonal Antibody to Claudin 2 (CLDN2) WB; IHC; ICC; IF.
Assay Kits CLR506Mo01 CLIA Kit for Claudin 2 (CLDN2) CLIA assay for Antigen Detection
ELR506Mo01 ELISA Kit for Claudin 2 (CLDN2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning of the human claudin-2 5'-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha."
J. Biol. Chem. 277:21361-21370(2002) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]

"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"SUMOylation of claudin-2."
Ann. N. Y. Acad. Sci. 1258:60-64(2012) [PubMed] [Europe PMC] [Abstract]

"Claudin-2 pore function requires an intramolecular disulfide bond between two conserved extracellular cysteines."
Am. J. Physiol. 305:C190-C196(2013) [PubMed] [Europe PMC] [Abstract]