Call Now

Carboxypeptidase A2, Pancreatic (CPA2)

Three different forms of human pancreatic procarboxypeptidase A have been isolated. The A1 and A2 forms are monomeric proteins with different biochemical properties. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues. The full-length cDNA encodes a deduced 417-amino acid protein, which includes a short leader sequence and a 94-amino acid long activation segment.
The human CPA2 protein shares 89% similarity with the rat CPA2 protein and 64% similarity with human CPA1. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues, in contrast to the A1 form, which shows a preference for the aliphatic C-terminal residues of peptide substrates.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR482Hu01 Recombinant Carboxypeptidase A2, Pancreatic (CPA2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR482Hu01 Monoclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) WB; IHC; ICC; IP.
PAR482Hu01 Polyclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) WB; IHC; ICC; IF.
Assay Kits CLR482Hu01 CLIA Kit for Carboxypeptidase A2, Pancreatic (CPA2) CLIA assay for Antigen Detection
ELR482Hu01 ELISA Kit for Carboxypeptidase A2, Pancreatic (CPA2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR482Mu01 Recombinant Carboxypeptidase A2, Pancreatic (CPA2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR482Mu01 Monoclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) WB; IHC; ICC; IP.
PAR482Mu01 Polyclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) WB; IHC; ICC; IF.
Assay Kits CLR482Mu01 CLIA Kit for Carboxypeptidase A2, Pancreatic (CPA2) CLIA assay for Antigen Detection
ELR482Mu01 ELISA Kit for Carboxypeptidase A2, Pancreatic (CPA2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR482Ra01 Recombinant Carboxypeptidase A2, Pancreatic (CPA2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR482Ra01 Monoclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) WB; IHC; ICC; IP.
PAR482Ra01 Polyclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) WB; IHC; ICC; IF.
Assay Kits CLR482Ra01 CLIA Kit for Carboxypeptidase A2, Pancreatic (CPA2) CLIA assay for Antigen Detection
ELR482Ra01 ELISA Kit for Carboxypeptidase A2, Pancreatic (CPA2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR482Ca01 Recombinant Carboxypeptidase A2, Pancreatic (CPA2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR482Ca01 Monoclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) WB; IHC; ICC; IP.
PAR482Ca01 Polyclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) WB; IHC; ICC; IF.
Assay Kits CLR482Ca01 CLIA Kit for Carboxypeptidase A2, Pancreatic (CPA2) CLIA assay for Antigen Detection
ELR482Ca01 ELISA Kit for Carboxypeptidase A2, Pancreatic (CPA2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR482Po01 Recombinant Carboxypeptidase A2, Pancreatic (CPA2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR482Po01 Monoclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) WB; IHC; ICC; IP.
PAR482Po01 Polyclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) WB; IHC; ICC; IF.
Assay Kits CLR482Po01 CLIA Kit for Carboxypeptidase A2, Pancreatic (CPA2) CLIA assay for Antigen Detection
ELR482Po01 ELISA Kit for Carboxypeptidase A2, Pancreatic (CPA2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR482Bo01 Recombinant Carboxypeptidase A2, Pancreatic (CPA2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR482Bo01 Monoclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) WB; IHC; ICC; IP.
PAR482Bo01 Polyclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) WB; IHC; ICC; IF.
Assay Kits CLR482Bo01 CLIA Kit for Carboxypeptidase A2, Pancreatic (CPA2) CLIA assay for Antigen Detection
ELR482Bo01 ELISA Kit for Carboxypeptidase A2, Pancreatic (CPA2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR482Rb01 Recombinant Carboxypeptidase A2, Pancreatic (CPA2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR482Rb01 Monoclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) WB; IHC; ICC; IP.
PAR482Rb01 Polyclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) WB; IHC; ICC; IF.
Assay Kits CLR482Rb01 CLIA Kit for Carboxypeptidase A2, Pancreatic (CPA2) CLIA assay for Antigen Detection
ELR482Rb01 ELISA Kit for Carboxypeptidase A2, Pancreatic (CPA2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR482Mo01 Recombinant Carboxypeptidase A2, Pancreatic (CPA2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR482Mo01 Monoclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) WB; IHC; ICC; IP.
PAR482Mo01 Polyclonal Antibody to Carboxypeptidase A2, Pancreatic (CPA2) WB; IHC; ICC; IF.
Assay Kits CLR482Mo01 CLIA Kit for Carboxypeptidase A2, Pancreatic (CPA2) CLIA assay for Antigen Detection
ELR482Mo01 ELISA Kit for Carboxypeptidase A2, Pancreatic (CPA2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 7: DNA sequence and biology."
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The sequence and conformation of human pancreatic procarboxypeptidase A2. cDNA cloning, sequence analysis, and three-dimensional model."
J. Biol. Chem. 270:6651-6657(1995) [PubMed] [Europe PMC] [Abstract]

"Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2."
Arch. Biochem. Biophys. 332:8-18(1996) [PubMed] [Europe PMC] [Abstract]

"Purification and properties of five different forms of human procarboxypeptidases."
Eur. J. Biochem. 179:609-616(1989) [PubMed] [Europe PMC] [Abstract]

"Separation of human pancreatic carboxypeptidase A isoenzymes by high performance liquid chromatography."
Biomed. Chromatogr. 7:143-145(1993) [PubMed] [Europe PMC] [Abstract]

"The three-dimensional structure of human procarboxypeptidase A2. Deciphering the basis of the inhibition, activation and intrinsic activity of the zymogen."
EMBO J. 16:6906-6913(1997) [PubMed] [Europe PMC] [Abstract]

"Characterisation and preliminary X-ray diffraction analysis of human pancreatic procarboxypeptidase A2."
FEBS Lett. 420:7-10(1997) [PubMed] [Europe PMC] [Abstract]

"Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2."
Nat. Struct. Biol. 7:322-328(2000) [PubMed] [Europe PMC] [Abstract]

"A large scale test of computational protein design: folding and stability of nine completely redesigned globular proteins."
J. Mol. Biol. 332:449-460(2003) [PubMed] [Europe PMC] [Abstract]

"NMR solution structure of the activation domain of human procarboxypeptidase A2."
Protein Sci. 12:296-305(2003) [PubMed] [Europe PMC] [Abstract]