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Complexin 2 (CPLX2)

921-L; CPX-2; CPX2; Synaphin-1

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene.
Sequence analysis determined that the rat Cplx1 and Cplx2 genes encode 134-amino acid, highly charged proteins that share 84% amino acid identity. Asp, glu, lys, and arg account for 44 to 47% of the complexin protein residues. The amino acid sequences, but not the nucleotide sequences, of mouse, rat, and human CPLX2 are 100% identical.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR466Hu01 Recombinant Complexin 2 (CPLX2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR466Hu01 Monoclonal Antibody to Complexin 2 (CPLX2) WB; IHC; ICC; IP.
PAR466Hu01 Polyclonal Antibody to Complexin 2 (CPLX2) WB; IHC; ICC; IF.
Assay Kits CLR466Hu01 CLIA Kit for Complexin 2 (CPLX2) CLIA assay for Antigen Detection
ELR466Hu01 ELISA Kit for Complexin 2 (CPLX2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR466Mu01 Recombinant Complexin 2 (CPLX2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR466Mu01 Monoclonal Antibody to Complexin 2 (CPLX2) WB; IHC; ICC; IP.
PAR466Mu01 Polyclonal Antibody to Complexin 2 (CPLX2) WB; IHC; ICC; IF.
Assay Kits CLR466Mu01 CLIA Kit for Complexin 2 (CPLX2) CLIA assay for Antigen Detection
ELR466Mu01 ELISA Kit for Complexin 2 (CPLX2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR466Ra01 Recombinant Complexin 2 (CPLX2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR466Ra01 Monoclonal Antibody to Complexin 2 (CPLX2) WB; IHC; ICC; IP.
PAR466Ra01 Polyclonal Antibody to Complexin 2 (CPLX2) WB; IHC; ICC; IF.
Assay Kits CLR466Ra01 CLIA Kit for Complexin 2 (CPLX2) CLIA assay for Antigen Detection
ELR466Ra01 ELISA Kit for Complexin 2 (CPLX2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR466Ca01 Recombinant Complexin 2 (CPLX2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR466Ca01 Monoclonal Antibody to Complexin 2 (CPLX2) WB; IHC; ICC; IP.
PAR466Ca01 Polyclonal Antibody to Complexin 2 (CPLX2) WB; IHC; ICC; IF.
Assay Kits CLR466Ca01 CLIA Kit for Complexin 2 (CPLX2) CLIA assay for Antigen Detection
ELR466Ca01 ELISA Kit for Complexin 2 (CPLX2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR466Po01 Recombinant Complexin 2 (CPLX2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR466Po01 Monoclonal Antibody to Complexin 2 (CPLX2) WB; IHC; ICC; IP.
PAR466Po01 Polyclonal Antibody to Complexin 2 (CPLX2) WB; IHC; ICC; IF.
Assay Kits CLR466Po01 CLIA Kit for Complexin 2 (CPLX2) CLIA assay for Antigen Detection
ELR466Po01 ELISA Kit for Complexin 2 (CPLX2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR466Bo01 Recombinant Complexin 2 (CPLX2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR466Bo01 Monoclonal Antibody to Complexin 2 (CPLX2) WB; IHC; ICC; IP.
PAR466Bo01 Polyclonal Antibody to Complexin 2 (CPLX2) WB; IHC; ICC; IF.
Assay Kits CLR466Bo01 CLIA Kit for Complexin 2 (CPLX2) CLIA assay for Antigen Detection
ELR466Bo01 ELISA Kit for Complexin 2 (CPLX2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR466Rb01 Recombinant Complexin 2 (CPLX2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR466Rb01 Monoclonal Antibody to Complexin 2 (CPLX2) WB; IHC; ICC; IP.
PAR466Rb01 Polyclonal Antibody to Complexin 2 (CPLX2) WB; IHC; ICC; IF.
Assay Kits CLR466Rb01 CLIA Kit for Complexin 2 (CPLX2) CLIA assay for Antigen Detection
ELR466Rb01 ELISA Kit for Complexin 2 (CPLX2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR466Mo01 Recombinant Complexin 2 (CPLX2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR466Mo01 Monoclonal Antibody to Complexin 2 (CPLX2) WB; IHC; ICC; IP.
PAR466Mo01 Polyclonal Antibody to Complexin 2 (CPLX2) WB; IHC; ICC; IF.
Assay Kits CLR466Mo01 CLIA Kit for Complexin 2 (CPLX2) CLIA assay for Antigen Detection
ELR466Mo01 ELISA Kit for Complexin 2 (CPLX2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Complexins: cytosolic proteins that regulate SNAP receptor function."
Cell 83:111-119(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structural organization of the human complexin 2 gene (CPLX2) and aspects of its functional activity."
Gene 359:127-137(2005) [PubMed] [Europe PMC] [Abstract]

"Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia."
Lancet 352:1669-1673(1998) [PubMed] [Europe PMC] [Abstract]

"Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins."
Brain Res. Bull. 55:569-578(2001) [PubMed] [Europe PMC] [Abstract]

"Cerebellar synaptic protein expression in schizophrenia."
Neuroscience 105:219-229(2001) [PubMed] [Europe PMC] [Abstract]

"Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements."
J. Neurocytol. 33:517-533(2004) [PubMed] [Europe PMC] [Abstract]