Crystallin Beta B2 (CRYbB2)

CCA2; CRYB2; CRYB2A; Beta-crystallin Bp

SPN	R452
HGNC	2398
MGI	88519
PubMed	22846113
RGD	2417
UniProt	P43320
Wiki	CRYBB2

Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins.CRYbB2, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B3. A chain-terminating mutation was found to cause type 2 cerulean cataracts.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR452Hu01	Recombinant Crystallin Beta B2 (CRYbB2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR452Hu01	Monoclonal Antibody to Crystallin Beta B2 (CRYbB2)	WB; IHC; ICC; IP.
Antibodies	PAR452Hu01	Polyclonal Antibody to Crystallin Beta B2 (CRYbB2)	WB; IHC; ICC; IF.
Assay Kits	CLR452Hu01	CLIA Kit for Crystallin Beta B2 (CRYbB2)	CLIA assay for Antigen Detection
Assay Kits	ELR452Hu01	ELISA Kit for Crystallin Beta B2 (CRYbB2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR452Mu01	Recombinant Crystallin Beta B2 (CRYbB2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR452Mu01	Monoclonal Antibody to Crystallin Beta B2 (CRYbB2)	WB; IHC; ICC; IP.
Antibodies	PAR452Mu01	Polyclonal Antibody to Crystallin Beta B2 (CRYbB2)	WB; IHC; ICC; IF.
Assay Kits	CLR452Mu01	CLIA Kit for Crystallin Beta B2 (CRYbB2)	CLIA assay for Antigen Detection
Assay Kits	ELR452Mu01	ELISA Kit for Crystallin Beta B2 (CRYbB2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR452Ra01	Recombinant Crystallin Beta B2 (CRYbB2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR452Ra01	Monoclonal Antibody to Crystallin Beta B2 (CRYbB2)	WB; IHC; ICC; IP.
Antibodies	PAR452Ra01	Polyclonal Antibody to Crystallin Beta B2 (CRYbB2)	WB; IHC; ICC; IF.
Assay Kits	CLR452Ra01	CLIA Kit for Crystallin Beta B2 (CRYbB2)	CLIA assay for Antigen Detection
Assay Kits	ELR452Ra01	ELISA Kit for Crystallin Beta B2 (CRYbB2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR452Ca01	Recombinant Crystallin Beta B2 (CRYbB2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR452Ca01	Monoclonal Antibody to Crystallin Beta B2 (CRYbB2)	WB; IHC; ICC; IP.
Antibodies	PAR452Ca01	Polyclonal Antibody to Crystallin Beta B2 (CRYbB2)	WB; IHC; ICC; IF.
Assay Kits	CLR452Ca01	CLIA Kit for Crystallin Beta B2 (CRYbB2)	CLIA assay for Antigen Detection
Assay Kits	ELR452Ca01	ELISA Kit for Crystallin Beta B2 (CRYbB2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR452Po01	Recombinant Crystallin Beta B2 (CRYbB2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR452Po01	Monoclonal Antibody to Crystallin Beta B2 (CRYbB2)	WB; IHC; ICC; IP.
Antibodies	PAR452Po01	Polyclonal Antibody to Crystallin Beta B2 (CRYbB2)	WB; IHC; ICC; IF.
Assay Kits	CLR452Po01	CLIA Kit for Crystallin Beta B2 (CRYbB2)	CLIA assay for Antigen Detection
Assay Kits	ELR452Po01	ELISA Kit for Crystallin Beta B2 (CRYbB2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR452Bo01	Recombinant Crystallin Beta B2 (CRYbB2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR452Bo01	Monoclonal Antibody to Crystallin Beta B2 (CRYbB2)	WB; IHC; ICC; IP.
Antibodies	PAR452Bo01	Polyclonal Antibody to Crystallin Beta B2 (CRYbB2)	WB; IHC; ICC; IF.
Assay Kits	CLR452Bo01	CLIA Kit for Crystallin Beta B2 (CRYbB2)	CLIA assay for Antigen Detection
Assay Kits	ELR452Bo01	ELISA Kit for Crystallin Beta B2 (CRYbB2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR452Rb01	Recombinant Crystallin Beta B2 (CRYbB2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR452Rb01	Monoclonal Antibody to Crystallin Beta B2 (CRYbB2)	WB; IHC; ICC; IP.
Antibodies	PAR452Rb01	Polyclonal Antibody to Crystallin Beta B2 (CRYbB2)	WB; IHC; ICC; IF.
Assay Kits	CLR452Rb01	CLIA Kit for Crystallin Beta B2 (CRYbB2)	CLIA assay for Antigen Detection
Assay Kits	ELR452Rb01	ELISA Kit for Crystallin Beta B2 (CRYbB2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR452Mo01	Recombinant Crystallin Beta B2 (CRYbB2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR452Mo01	Monoclonal Antibody to Crystallin Beta B2 (CRYbB2)	WB; IHC; ICC; IP.
Antibodies	PAR452Mo01	Polyclonal Antibody to Crystallin Beta B2 (CRYbB2)	WB; IHC; ICC; IF.
Assay Kits	CLR452Mo01	CLIA Kit for Crystallin Beta B2 (CRYbB2)	CLIA assay for Antigen Detection
Assay Kits	ELR452Mo01	ELISA Kit for Crystallin Beta B2 (CRYbB2)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Sequence of the human lens beta B2-crystallin-encoding cDNA."
Gene 133:295-299(1993) [PubMed] [Europe PMC] [Abstract]

"Autosomal dominant cerulean cataract is associated with a chain termination mutation in the human beta-crystallin gene CRYBB2."
Hum. Mol. Genet. 6:665-668(1997) [PubMed] [Europe PMC] [Abstract]

"A genome annotation-driven approach to cloning the human ORFeome."
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Amino acid sequence of human lens beta B2-crystallin."
Protein Sci. 2:290-291(1993) [PubMed] [Europe PMC] [Abstract]

"Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens."
J. Biol. Chem. 272:2268-2275(1997) [PubMed] [Europe PMC] [Abstract]

"Two-dimensional gel electrophoretic analysis of human lens proteins."
Curr. Eye Res. 11:669-677(1992) [PubMed] [Europe PMC] [Abstract]

"Post-translational modifications of water-soluble human lens crystallins from young adults."
J. Biol. Chem. 269:12494-12502(1994) [PubMed] [Europe PMC] [Abstract]

"The major in vivo modifications of the human water-insoluble lens crystallins are disulfide bonds, deamidation, methionine oxidation and backbone cleavage."
Exp. Eye Res. 71:195-207(2000) [PubMed] [Europe PMC] [Abstract]

"Genetic heterogeneity of the Coppock-like cataract: a mutation in CRYBB2 on chromosome 22q11.2."
Invest. Ophthalmol. Vis. Sci. 41:159-165(2000) [PubMed] [Europe PMC] [Abstract]

"Mutation of interfaces in domain-swapped human betaB2-crystallin."
Protein Sci. 16:615-625(2007) [PubMed] [Europe PMC] [Abstract]