C-Terminal Binding Protein 2 (CTBP2)

Ribeye

SPN	R439
HGNC	2495
MGI	1201686
PubMed	16999872
RGD	68372
UniProt	P56545
Wiki	CTBP2

CTBP2 produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10.Interacts with the C-terminus of adenovirus E1A protein. Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with HIPK2 and ZNF217. Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes expression By similarity. Interacts with PNN, NRIP1 and WIZ

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR439Hu01	Recombinant C-Terminal Binding Protein 2 (CTBP2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR439Hu01	Monoclonal Antibody to C-Terminal Binding Protein 2 (CTBP2)	WB; IHC; ICC; IP.
Antibodies	PAR439Hu01	Polyclonal Antibody to C-Terminal Binding Protein 2 (CTBP2)	WB; IHC; ICC; IF.
Assay Kits	CLR439Hu01	CLIA Kit for C-Terminal Binding Protein 2 (CTBP2)	CLIA assay for Antigen Detection
Assay Kits	ELR439Hu01	ELISA Kit for C-Terminal Binding Protein 2 (CTBP2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR439Mu01	Recombinant C-Terminal Binding Protein 2 (CTBP2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR439Mu01	Monoclonal Antibody to C-Terminal Binding Protein 2 (CTBP2)	WB; IHC; ICC; IP.
Antibodies	PAR439Mu01	Polyclonal Antibody to C-Terminal Binding Protein 2 (CTBP2)	WB; IHC; ICC; IF.
Assay Kits	CLR439Mu01	CLIA Kit for C-Terminal Binding Protein 2 (CTBP2)	CLIA assay for Antigen Detection
Assay Kits	ELR439Mu01	ELISA Kit for C-Terminal Binding Protein 2 (CTBP2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR439Ra01	Recombinant C-Terminal Binding Protein 2 (CTBP2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR439Ra01	Monoclonal Antibody to C-Terminal Binding Protein 2 (CTBP2)	WB; IHC; ICC; IP.
Antibodies	PAR439Ra01	Polyclonal Antibody to C-Terminal Binding Protein 2 (CTBP2)	WB; IHC; ICC; IF.
Assay Kits	CLR439Ra01	CLIA Kit for C-Terminal Binding Protein 2 (CTBP2)	CLIA assay for Antigen Detection
Assay Kits	ELR439Ra01	ELISA Kit for C-Terminal Binding Protein 2 (CTBP2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR439Ca01	Recombinant C-Terminal Binding Protein 2 (CTBP2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR439Ca01	Monoclonal Antibody to C-Terminal Binding Protein 2 (CTBP2)	WB; IHC; ICC; IP.
Antibodies	PAR439Ca01	Polyclonal Antibody to C-Terminal Binding Protein 2 (CTBP2)	WB; IHC; ICC; IF.
Assay Kits	CLR439Ca01	CLIA Kit for C-Terminal Binding Protein 2 (CTBP2)	CLIA assay for Antigen Detection
Assay Kits	ELR439Ca01	ELISA Kit for C-Terminal Binding Protein 2 (CTBP2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR439Po01	Recombinant C-Terminal Binding Protein 2 (CTBP2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR439Po01	Monoclonal Antibody to C-Terminal Binding Protein 2 (CTBP2)	WB; IHC; ICC; IP.
Antibodies	PAR439Po01	Polyclonal Antibody to C-Terminal Binding Protein 2 (CTBP2)	WB; IHC; ICC; IF.
Assay Kits	CLR439Po01	CLIA Kit for C-Terminal Binding Protein 2 (CTBP2)	CLIA assay for Antigen Detection
Assay Kits	ELR439Po01	ELISA Kit for C-Terminal Binding Protein 2 (CTBP2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR439Bo01	Recombinant C-Terminal Binding Protein 2 (CTBP2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR439Bo01	Monoclonal Antibody to C-Terminal Binding Protein 2 (CTBP2)	WB; IHC; ICC; IP.
Antibodies	PAR439Bo01	Polyclonal Antibody to C-Terminal Binding Protein 2 (CTBP2)	WB; IHC; ICC; IF.
Assay Kits	CLR439Bo01	CLIA Kit for C-Terminal Binding Protein 2 (CTBP2)	CLIA assay for Antigen Detection
Assay Kits	ELR439Bo01	ELISA Kit for C-Terminal Binding Protein 2 (CTBP2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR439Rb01	Recombinant C-Terminal Binding Protein 2 (CTBP2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR439Rb01	Monoclonal Antibody to C-Terminal Binding Protein 2 (CTBP2)	WB; IHC; ICC; IP.
Antibodies	PAR439Rb01	Polyclonal Antibody to C-Terminal Binding Protein 2 (CTBP2)	WB; IHC; ICC; IF.
Assay Kits	CLR439Rb01	CLIA Kit for C-Terminal Binding Protein 2 (CTBP2)	CLIA assay for Antigen Detection
Assay Kits	ELR439Rb01	ELISA Kit for C-Terminal Binding Protein 2 (CTBP2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR439Mo01	Recombinant C-Terminal Binding Protein 2 (CTBP2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR439Mo01	Monoclonal Antibody to C-Terminal Binding Protein 2 (CTBP2)	WB; IHC; ICC; IP.
Antibodies	PAR439Mo01	Polyclonal Antibody to C-Terminal Binding Protein 2 (CTBP2)	WB; IHC; ICC; IF.
Assay Kits	CLR439Mo01	CLIA Kit for C-Terminal Binding Protein 2 (CTBP2)	CLIA assay for Antigen Detection
Assay Kits	ELR439Mo01	ELISA Kit for C-Terminal Binding Protein 2 (CTBP2)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3."
Genomics 47:294-299(1998) [PubMed] [Europe PMC] [Abstract]

"RIBEYE, a component of synaptic ribbons: a protein's journey through evolution provides insight into synaptic ribbon function."
Neuron 28:857-872(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation."
Proc. Natl. Acad. Sci. U.S.A. 92:10467-10471(1995) [PubMed] [Europe PMC] [Abstract]

"Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene."
Mol. Cell. Biol. 24:10223-10235(2004) [PubMed] [Europe PMC] [Abstract]

"Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition."
Nucleic Acids Res. 32:1957-1966(2004) [PubMed] [Europe PMC] [Abstract]

"Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP."
J. Biol. Chem. 281:20120-20128(2006) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H)."
Submitted (FEB-2009) to the PDB data bank