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Docking Protein 3 (DOK3)

DOKL; Downstream of tyrosine kinase 3

The deduced 444-amino acid mouse protein contains an N-terminal PH domain, a central PTB domain, and a proline-rich C-terminal domain. Dokl is relatively serine/threonine-rich overall and contains several potential phosphorylation sites for ser/thr protein kinases. Dokl shares 60% and 57% sequence similarity with p62dok (DOK1) over the PH and PTB domains, respectively, with lower similarity over the C-terminal regions. Northern blot analysis of mouse tissues detected several species with high expression in spleen and lung and low levels in other tissues. RNAse protection studies detected very high Dokl expression in bone marrow and spleen, low expression in thymus, and no expression in NIH3T3 cells. Immunofluorescence studies localized Dokl to the cytoplasm in NIH3T3 cells.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR425Hu01 Recombinant Docking Protein 3 (DOK3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR425Hu01 Monoclonal Antibody to Docking Protein 3 (DOK3) WB; IHC; ICC; IP.
PAR425Hu01 Polyclonal Antibody to Docking Protein 3 (DOK3) WB; IHC; ICC; IF.
Assay Kits CLR425Hu01 CLIA Kit for Docking Protein 3 (DOK3) CLIA assay for Antigen Detection
ELR425Hu01 ELISA Kit for Docking Protein 3 (DOK3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR425Mu01 Recombinant Docking Protein 3 (DOK3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR425Mu01 Monoclonal Antibody to Docking Protein 3 (DOK3) WB; IHC; ICC; IP.
PAR425Mu01 Polyclonal Antibody to Docking Protein 3 (DOK3) WB; IHC; ICC; IF.
Assay Kits CLR425Mu01 CLIA Kit for Docking Protein 3 (DOK3) CLIA assay for Antigen Detection
ELR425Mu01 ELISA Kit for Docking Protein 3 (DOK3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR425Ra01 Recombinant Docking Protein 3 (DOK3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR425Ra01 Monoclonal Antibody to Docking Protein 3 (DOK3) WB; IHC; ICC; IP.
PAR425Ra01 Polyclonal Antibody to Docking Protein 3 (DOK3) WB; IHC; ICC; IF.
Assay Kits CLR425Ra01 CLIA Kit for Docking Protein 3 (DOK3) CLIA assay for Antigen Detection
ELR425Ra01 ELISA Kit for Docking Protein 3 (DOK3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR425Ca01 Recombinant Docking Protein 3 (DOK3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR425Ca01 Monoclonal Antibody to Docking Protein 3 (DOK3) WB; IHC; ICC; IP.
PAR425Ca01 Polyclonal Antibody to Docking Protein 3 (DOK3) WB; IHC; ICC; IF.
Assay Kits CLR425Ca01 CLIA Kit for Docking Protein 3 (DOK3) CLIA assay for Antigen Detection
ELR425Ca01 ELISA Kit for Docking Protein 3 (DOK3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR425Po01 Recombinant Docking Protein 3 (DOK3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR425Po01 Monoclonal Antibody to Docking Protein 3 (DOK3) WB; IHC; ICC; IP.
PAR425Po01 Polyclonal Antibody to Docking Protein 3 (DOK3) WB; IHC; ICC; IF.
Assay Kits CLR425Po01 CLIA Kit for Docking Protein 3 (DOK3) CLIA assay for Antigen Detection
ELR425Po01 ELISA Kit for Docking Protein 3 (DOK3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR425Bo01 Recombinant Docking Protein 3 (DOK3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR425Bo01 Monoclonal Antibody to Docking Protein 3 (DOK3) WB; IHC; ICC; IP.
PAR425Bo01 Polyclonal Antibody to Docking Protein 3 (DOK3) WB; IHC; ICC; IF.
Assay Kits CLR425Bo01 CLIA Kit for Docking Protein 3 (DOK3) CLIA assay for Antigen Detection
ELR425Bo01 ELISA Kit for Docking Protein 3 (DOK3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR425Rb01 Recombinant Docking Protein 3 (DOK3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR425Rb01 Monoclonal Antibody to Docking Protein 3 (DOK3) WB; IHC; ICC; IP.
PAR425Rb01 Polyclonal Antibody to Docking Protein 3 (DOK3) WB; IHC; ICC; IF.
Assay Kits CLR425Rb01 CLIA Kit for Docking Protein 3 (DOK3) CLIA assay for Antigen Detection
ELR425Rb01 ELISA Kit for Docking Protein 3 (DOK3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR425Mo01 Recombinant Docking Protein 3 (DOK3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR425Mo01 Monoclonal Antibody to Docking Protein 3 (DOK3) WB; IHC; ICC; IP.
PAR425Mo01 Polyclonal Antibody to Docking Protein 3 (DOK3) WB; IHC; ICC; IF.
Assay Kits CLR425Mo01 CLIA Kit for Docking Protein 3 (DOK3) CLIA assay for Antigen Detection
ELR425Mo01 ELISA Kit for Docking Protein 3 (DOK3) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"DOK4 and DOK5: new Dok-related genes expressed in human T cells."
Genes Immun. 4:40-45(2003) [PubMed] [Europe PMC] [Abstract]

"Phosphoproteome of resting human platelets."
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]