Carnosine Dipeptidase 1 (CNDP1)

CN1; CPGL2; Beta-Ala-His Dipeptidase; Metallopeptidase M20; Carnosinase 1; Serum carnosinase; Glutamate Carboxypeptidase-Like Protein 2

SPN	R411
HGNC	20675
MGI	2451097
PubMed	23342076
RGD	1359493
UniProt	Q96KN2
Wiki	CNDP1

CNDP1 encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region.The mouse and rat CN1 homologs do not have an N-terminal signal peptide and are expressed exclusively in kidney. Western blot analysis detected multiple protein bands in extracts of plasma and cerebrospinal fluid and 2 bands in cortex and hippocampus. Immunohistochemical analysis detected CN1 in the cytosol of pyramidal neurons in the hippocampus and in large and small neurons of the temporal cortex. In subcortical white matter, CN1 was expressed by small cells, presumably glial cells, and neuronal fibers.

Reference

"Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1."
Diabetes 54:2320-2327(2005) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 18."
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium."
Clin. Chim. Acta 123:221-231(1982) [PubMed] [Europe PMC] [Abstract]

"Homocarnosinosis: lack of serum carnosinase is the defect probably responsible for elevated brain and CSF homocarnosine."
Clin. Chim. Acta 132:157-165(1983) [PubMed] [Europe PMC] [Abstract]

"Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase."
J. Biol. Chem. 278:6521-6531(2003) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human carnosine dipeptidase 1."
Submitted (JUL-2011) to the PDB data bank