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Spondin 1 (SPON1)

VSGP; F-spondin; F-spondin,Extracellular Matrix Protein; Vascular smooth muscle cell growth-promoting factor

Spondin-1 is a protein contains 807 aminoacids and is structurally composed of six thrombospondin domains, one reelin domain, and one spondin domain.The deduced 624-amino acid partial SPON1 protein shares 96.8% amino acid sequence identity with the rat F-spondin precursor across 624 residues.SPON1 expression in lung, lower expression in brain, heart, kidney, liver, and testis, and lowest expression in pancreas, skeletal muscle, and ovary; no expression was found in spleen. In vitro binding assays using mutated human proteins confirmed that SPON1 specifically bound to the central APP domain (CAPPD). SPON1 inhibited APP cleavage by BACE1, the primary beta-secretase involved in APP processing. Binding also impaired APP- and FE65-dependent transactivation of the chromosome remodeling factor TIP60 .

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR402Hu01 Recombinant Spondin 1 (SPON1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR402Hu01 Monoclonal Antibody to Spondin 1 (SPON1) WB; IHC; ICC; IP.
PAR402Hu01 Polyclonal Antibody to Spondin 1 (SPON1) WB; IHC; ICC; IF.
Assay Kits CLR402Hu01 CLIA Kit for Spondin 1 (SPON1) CLIA assay for Antigen Detection
ELR402Hu01 ELISA Kit for Spondin 1 (SPON1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR402Mu01 Recombinant Spondin 1 (SPON1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR402Mu01 Monoclonal Antibody to Spondin 1 (SPON1) WB; IHC; ICC; IP.
PAR402Mu01 Polyclonal Antibody to Spondin 1 (SPON1) WB; IHC; ICC; IF.
Assay Kits CLR402Mu01 CLIA Kit for Spondin 1 (SPON1) CLIA assay for Antigen Detection
ELR402Mu01 ELISA Kit for Spondin 1 (SPON1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR402Ra01 Recombinant Spondin 1 (SPON1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR402Ra01 Monoclonal Antibody to Spondin 1 (SPON1) WB; IHC; ICC; IP.
PAR402Ra01 Polyclonal Antibody to Spondin 1 (SPON1) WB; IHC; ICC; IF.
Assay Kits CLR402Ra01 CLIA Kit for Spondin 1 (SPON1) CLIA assay for Antigen Detection
ELR402Ra01 ELISA Kit for Spondin 1 (SPON1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR402Ca01 Recombinant Spondin 1 (SPON1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR402Ca01 Monoclonal Antibody to Spondin 1 (SPON1) WB; IHC; ICC; IP.
PAR402Ca01 Polyclonal Antibody to Spondin 1 (SPON1) WB; IHC; ICC; IF.
Assay Kits CLR402Ca01 CLIA Kit for Spondin 1 (SPON1) CLIA assay for Antigen Detection
ELR402Ca01 ELISA Kit for Spondin 1 (SPON1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR402Po01 Recombinant Spondin 1 (SPON1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR402Po01 Monoclonal Antibody to Spondin 1 (SPON1) WB; IHC; ICC; IP.
PAR402Po01 Polyclonal Antibody to Spondin 1 (SPON1) WB; IHC; ICC; IF.
Assay Kits CLR402Po01 CLIA Kit for Spondin 1 (SPON1) CLIA assay for Antigen Detection
ELR402Po01 ELISA Kit for Spondin 1 (SPON1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR402Bo01 Recombinant Spondin 1 (SPON1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR402Bo01 Monoclonal Antibody to Spondin 1 (SPON1) WB; IHC; ICC; IP.
PAR402Bo01 Polyclonal Antibody to Spondin 1 (SPON1) WB; IHC; ICC; IF.
Assay Kits CLR402Bo01 CLIA Kit for Spondin 1 (SPON1) CLIA assay for Antigen Detection
ELR402Bo01 ELISA Kit for Spondin 1 (SPON1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR402Rb01 Recombinant Spondin 1 (SPON1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR402Rb01 Monoclonal Antibody to Spondin 1 (SPON1) WB; IHC; ICC; IP.
PAR402Rb01 Polyclonal Antibody to Spondin 1 (SPON1) WB; IHC; ICC; IF.
Assay Kits CLR402Rb01 CLIA Kit for Spondin 1 (SPON1) CLIA assay for Antigen Detection
ELR402Rb01 ELISA Kit for Spondin 1 (SPON1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPR402Mo01 Recombinant Spondin 1 (SPON1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAR402Mo01 Monoclonal Antibody to Spondin 1 (SPON1) WB; IHC; ICC; IP.
PAR402Mo01 Polyclonal Antibody to Spondin 1 (SPON1) WB; IHC; ICC; IF.
Assay Kits CLR402Mo01 CLIA Kit for Spondin 1 (SPON1) CLIA assay for Antigen Detection
ELR402Mo01 ELISA Kit for Spondin 1 (SPON1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]

"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]

"C-mannosylation and O-fucosylation of thrombospondin type 1 repeats."
Mol. Cell. Proteomics 1:11-18(2002) [PubMed] [Europe PMC] [Abstract]

"Structure of the F-spondin reeler domain reveals a unique beta-sandwich fold with a deformable disulfide-bonded loop."
Acta Crystallogr. D 64:1138-1145(2008) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of the heparin-binding reelin-N domain of f-spondin."
J. Mol. Biol. 381:1213-1223(2008) [PubMed] [Europe PMC] [Abstract]