Fatty Acid Desaturase 2 (FADS2)

LLCDL2; FADSD6; D6D; TU13; DES6; Delta-6-Desaturase; Delta(6) fatty acid desaturase

SPN	R380
HGNC	3575
MGI	1930079
PubMed	23737301
RGD	68339
UniProt	O95864
Wiki	FADS2

Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. FADS2 is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization.It was reported the FADS2 interacts with breastfeeding such that breast-fed children with the "C" version of the gene appear about 7 intelligence quotient (IQ) points higher than those with the less common "G" version .

Reference

"Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase."
J. Biol. Chem. 274:471-477(1999) [PubMed] [Europe PMC] [Abstract]

"cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family."
Genomics 66:175-183(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The E-box like sterol regulatory element mediates the suppression of human Delta-6 desaturase gene by highly unsaturated fatty acids."
Biochem. Biophys. Res. Commun. 296:111-117(2002) [PubMed] [Europe PMC] [Abstract]

"Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity."
J. Invest. Dermatol. 120:707-714(2003) [PubMed] [Europe PMC] [Abstract]

Erratum
J. Invest. Dermatol. 121:434-434(2003)

"Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element."
J. Lipid Res. 44:686-695(2003) [PubMed] [Europe PMC] [Abstract]

"Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer."
Int. J. Mol. Med. 12:253-257(2003) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]