Fibronectin Leucine Rich Transmembrane Protein 3 (FLRT3)

Fibronectin-like domain-containing leucine-rich transmembrane protein 3; Leucine-rich repeat transmembrane protein FLRT3

SPN	R344
HGNC	3762
MGI	1918686
PubMed	19492039
RGD	1566005
UniProt	Q9NZU0
Wiki	FLRT3

FLRT3 shares 55% amino acid sequence identity with FLRT1 and 44% identity with FLRT2. FLRT3 is expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.

The predicted 649-amino acid FLRT3 protein contains a putative N-terminal signal sequence, 10 leucine-rich repeats (LRRs) flanked by N- and C-terminal cysteine-rich regions, a fibronectin-/collagen-like domain, a transmembrane domain, and an intracellular C-terminal tail. FLRT3 has 4 potential N-glycosylation sites in its extracellular region. FLRT3 shares 55% amino acid sequence identity with FLRT1 and 44% identity with FLRT2 .

Reference

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