Flavin Containing Monooxygenase 1 (FMO1)

Dimethylaniline oxidase 1; Fetal hepatic flavin-containing monooxygenase 1

SPN	R339
HGNC	3769
MGI	1310002
PubMed	21540762
RGD	2622
UniProt	Q01740
Wiki	FMO1

Dimethylaniline monooxygenase [N-oxide-forming] 1 is an enzyme that by the FMO1 gene.Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region.

Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.

Reference

"Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1)."
J. Biol. Chem. 266:12379-12385(1991) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans."
Drug Metab. Dispos. 31:187-193(2003) [PubMed] [Europe PMC] [Abstract]