Hyaluronan Synthase 2 (HAS2)

Hyaluronate synthase 2; Hyaluronic acid synthase 2

SPN	R325
HGNC	4819
MGI	107821
PubMed	19633173
RGD	2781
UniProt	Q92819
Wiki	HAS2

HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis.

HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR325Hu01	Recombinant Hyaluronan Synthase 2 (HAS2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR325Hu01	Monoclonal Antibody to Hyaluronan Synthase 2 (HAS2)	WB; IHC; ICC; IP.
Antibodies	PAR325Hu01	Polyclonal Antibody to Hyaluronan Synthase 2 (HAS2)	WB; IHC; ICC; IF.
Assay Kits	CLR325Hu01	CLIA Kit for Hyaluronan Synthase 2 (HAS2)	CLIA assay for Antigen Detection
Assay Kits	ELR325Hu01	ELISA Kit for Hyaluronan Synthase 2 (HAS2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR325Mu01	Recombinant Hyaluronan Synthase 2 (HAS2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR325Mu01	Monoclonal Antibody to Hyaluronan Synthase 2 (HAS2)	WB; IHC; ICC; IP.
Antibodies	PAR325Mu01	Polyclonal Antibody to Hyaluronan Synthase 2 (HAS2)	WB; IHC; ICC; IF.
Assay Kits	CLR325Mu01	CLIA Kit for Hyaluronan Synthase 2 (HAS2)	CLIA assay for Antigen Detection
Assay Kits	ELR325Mu01	ELISA Kit for Hyaluronan Synthase 2 (HAS2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR325Ra01	Recombinant Hyaluronan Synthase 2 (HAS2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR325Ra01	Monoclonal Antibody to Hyaluronan Synthase 2 (HAS2)	WB; IHC; ICC; IP.
Antibodies	PAR325Ra01	Polyclonal Antibody to Hyaluronan Synthase 2 (HAS2)	WB; IHC; ICC; IF.
Assay Kits	CLR325Ra01	CLIA Kit for Hyaluronan Synthase 2 (HAS2)	CLIA assay for Antigen Detection
Assay Kits	ELR325Ra01	ELISA Kit for Hyaluronan Synthase 2 (HAS2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR325Ca01	Recombinant Hyaluronan Synthase 2 (HAS2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR325Ca01	Monoclonal Antibody to Hyaluronan Synthase 2 (HAS2)	WB; IHC; ICC; IP.
Antibodies	PAR325Ca01	Polyclonal Antibody to Hyaluronan Synthase 2 (HAS2)	WB; IHC; ICC; IF.
Assay Kits	CLR325Ca01	CLIA Kit for Hyaluronan Synthase 2 (HAS2)	CLIA assay for Antigen Detection
Assay Kits	ELR325Ca01	ELISA Kit for Hyaluronan Synthase 2 (HAS2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR325Po01	Recombinant Hyaluronan Synthase 2 (HAS2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR325Po01	Monoclonal Antibody to Hyaluronan Synthase 2 (HAS2)	WB; IHC; ICC; IP.
Antibodies	PAR325Po01	Polyclonal Antibody to Hyaluronan Synthase 2 (HAS2)	WB; IHC; ICC; IF.
Assay Kits	CLR325Po01	CLIA Kit for Hyaluronan Synthase 2 (HAS2)	CLIA assay for Antigen Detection
Assay Kits	ELR325Po01	ELISA Kit for Hyaluronan Synthase 2 (HAS2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR325Bo01	Recombinant Hyaluronan Synthase 2 (HAS2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR325Bo01	Monoclonal Antibody to Hyaluronan Synthase 2 (HAS2)	WB; IHC; ICC; IP.
Antibodies	PAR325Bo01	Polyclonal Antibody to Hyaluronan Synthase 2 (HAS2)	WB; IHC; ICC; IF.
Assay Kits	CLR325Bo01	CLIA Kit for Hyaluronan Synthase 2 (HAS2)	CLIA assay for Antigen Detection
Assay Kits	ELR325Bo01	ELISA Kit for Hyaluronan Synthase 2 (HAS2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR325Rb01	Recombinant Hyaluronan Synthase 2 (HAS2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR325Rb01	Monoclonal Antibody to Hyaluronan Synthase 2 (HAS2)	WB; IHC; ICC; IP.
Antibodies	PAR325Rb01	Polyclonal Antibody to Hyaluronan Synthase 2 (HAS2)	WB; IHC; ICC; IF.
Assay Kits	CLR325Rb01	CLIA Kit for Hyaluronan Synthase 2 (HAS2)	CLIA assay for Antigen Detection
Assay Kits	ELR325Rb01	ELISA Kit for Hyaluronan Synthase 2 (HAS2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR325Mo01	Recombinant Hyaluronan Synthase 2 (HAS2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR325Mo01	Monoclonal Antibody to Hyaluronan Synthase 2 (HAS2)	WB; IHC; ICC; IP.
Antibodies	PAR325Mo01	Polyclonal Antibody to Hyaluronan Synthase 2 (HAS2)	WB; IHC; ICC; IF.
Assay Kits	CLR325Mo01	CLIA Kit for Hyaluronan Synthase 2 (HAS2)	CLIA assay for Antigen Detection
Assay Kits	ELR325Mo01	ELISA Kit for Hyaluronan Synthase 2 (HAS2)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular identification of a putative human hyaluronan synthase."
J. Biol. Chem. 271:22945-22948(1996) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement."
Cancer Genet. Cytogenet. 156:183-184(2005) [PubMed] [Europe PMC] [Abstract]