Lysyl Oxidase Like Protein 1 (LOXL1)
LOL; LOXL; Lysyl oxidase homolog 1
LOXL1 encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function.
The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.Polymorphisms of the gene are associated with the pseudoexfoliation syndrome.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR246Hu01 | Recombinant Lysyl Oxidase Like Protein 1 (LOXL1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR246Hu01 | Monoclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) | WB; IHC; ICC; IP. |
| PAR246Hu01 | Polyclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR246Hu01 | CLIA Kit for Lysyl Oxidase Like Protein 1 (LOXL1) | CLIA assay for Antigen Detection |
| ELR246Hu01 | ELISA Kit for Lysyl Oxidase Like Protein 1 (LOXL1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR246Mu01 | Recombinant Lysyl Oxidase Like Protein 1 (LOXL1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR246Mu01 | Monoclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) | WB; IHC; ICC; IP. |
| PAR246Mu01 | Polyclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR246Mu01 | CLIA Kit for Lysyl Oxidase Like Protein 1 (LOXL1) | CLIA assay for Antigen Detection |
| ELR246Mu01 | ELISA Kit for Lysyl Oxidase Like Protein 1 (LOXL1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR246Ra01 | Recombinant Lysyl Oxidase Like Protein 1 (LOXL1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR246Ra01 | Monoclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) | WB; IHC; ICC; IP. |
| PAR246Ra01 | Polyclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR246Ra01 | CLIA Kit for Lysyl Oxidase Like Protein 1 (LOXL1) | CLIA assay for Antigen Detection |
| ELR246Ra01 | ELISA Kit for Lysyl Oxidase Like Protein 1 (LOXL1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR246Ca01 | Recombinant Lysyl Oxidase Like Protein 1 (LOXL1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR246Ca01 | Monoclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) | WB; IHC; ICC; IP. |
| PAR246Ca01 | Polyclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR246Ca01 | CLIA Kit for Lysyl Oxidase Like Protein 1 (LOXL1) | CLIA assay for Antigen Detection |
| ELR246Ca01 | ELISA Kit for Lysyl Oxidase Like Protein 1 (LOXL1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR246Po01 | Recombinant Lysyl Oxidase Like Protein 1 (LOXL1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR246Po01 | Monoclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) | WB; IHC; ICC; IP. |
| PAR246Po01 | Polyclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR246Po01 | CLIA Kit for Lysyl Oxidase Like Protein 1 (LOXL1) | CLIA assay for Antigen Detection |
| ELR246Po01 | ELISA Kit for Lysyl Oxidase Like Protein 1 (LOXL1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR246Bo01 | Recombinant Lysyl Oxidase Like Protein 1 (LOXL1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR246Bo01 | Monoclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) | WB; IHC; ICC; IP. |
| PAR246Bo01 | Polyclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR246Bo01 | CLIA Kit for Lysyl Oxidase Like Protein 1 (LOXL1) | CLIA assay for Antigen Detection |
| ELR246Bo01 | ELISA Kit for Lysyl Oxidase Like Protein 1 (LOXL1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR246Rb01 | Recombinant Lysyl Oxidase Like Protein 1 (LOXL1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR246Rb01 | Monoclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) | WB; IHC; ICC; IP. |
| PAR246Rb01 | Polyclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR246Rb01 | CLIA Kit for Lysyl Oxidase Like Protein 1 (LOXL1) | CLIA assay for Antigen Detection |
| ELR246Rb01 | ELISA Kit for Lysyl Oxidase Like Protein 1 (LOXL1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR246Mo01 | Recombinant Lysyl Oxidase Like Protein 1 (LOXL1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR246Mo01 | Monoclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) | WB; IHC; ICC; IP. |
| PAR246Mo01 | Polyclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR246Mo01 | CLIA Kit for Lysyl Oxidase Like Protein 1 (LOXL1) | CLIA assay for Antigen Detection |
| ELR246Mo01 | ELISA Kit for Lysyl Oxidase Like Protein 1 (LOXL1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A novel human cDNA with a predicted protein similar to lysyl oxidase maps to chromosome 15q24-q25."
J. Biol. Chem. 268:18435-18437(1993) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma."
Science 317:1397-1400(2007) [PubMed] [Europe PMC] [Abstract]
"Ancestral LOXL1 variants are associated with pseudoexfoliation in Caucasian Australians but with markedly lower penetrance than in Nordic people."
Hum. Mol. Genet. 17:710-716(2008) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Association of LOXL1 gene with Finnish exfoliation syndrome patients."
J. Hum. Genet. 54:289-297(2009) [PubMed] [Europe PMC] [Abstract]